Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation

Our previous study showed that growth arrest- and DNA damage-inducible gene 153 (GAD153/CHOP) plays an important role in intermittent hypoxia- (IH-) induced apoptosis and impaired synaptic plasticity. This study is aimed at determining which signaling pathway is activated to induce CHOP and the role...

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Bibliographic Details
Main Authors: Linhao Xu, Yanli Bi, Yizhou Xu, Yihao Wu, Xiaoxue Du, Yixuan Mou, Jian Chen
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2021/4090441

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