Vasculitic neuropathy in elderly: A study from a tertiary care university hospital in South India
Objective: To describe clinical, electrophysiological, and histopathological profile of vasculitic neuropathy in elderly subjects aged 65 years or more. Design: Retrospective chart review. Setting: Departments of Neurology and Neuropathology, National Institute of Mental Health and Neurosciences, Be...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=3;spage=323;epage=326;aulast=Lawrence |
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| author | Anish Lawrence Madhu Nagappa Anita Mahadevan Arun B Taly |
| author_facet | Anish Lawrence Madhu Nagappa Anita Mahadevan Arun B Taly |
| author_sort | Anish Lawrence |
| collection | DOAJ |
| description | Objective: To describe clinical, electrophysiological, and histopathological profile of vasculitic neuropathy in elderly subjects aged 65 years or more. Design: Retrospective chart review. Setting: Departments of Neurology and Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India. Patients and Methods: Elderly subjects, diagnosed vasculitic neuropathy by nerve biopsy over one decade, were studied. Results: The cohort consisted of 46 subjects. Symptom duration was 21.54 ± 33.53 months. Onset was chronic in majority (82.6%). Key features included paresthesias (89%), weakness (80%), sensory loss (70%), wasting (63%), and relapsing-remitting course (6.5%). Most Common clinico-electrophysiological patterns were distal symmetrical sensorimotor polyneuropathy - 19, mononeuritis multiplex - 9, and asymmetric sensorimotor neuropathy - 10. Diagnosis of vasculitis was not suspected before biopsy in 31 (67.3%). Nerve biopsy revealed definite vasculitis - 12, probable - 10, and possible - 24. Treatment included immunomodulatory agents (41), symptomatic medications only (9), and antiretroviral therapy (1). Twenty-four patients were followed up for mean period of 6.5 months. Outcome at last follow-up was improved (13), unchanged (8), and worsened (3). Conclusion: Vasculitis is an important, treatable cause of neuropathy in elderly. Nerve biopsy should be used judiciously for early diagnosis and appropriate treatment. |
| first_indexed | 2024-12-22T22:58:31Z |
| format | Article |
| id | doaj.art-4dd294ea08454500a889b88d1da5730a |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-22T22:58:31Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-4dd294ea08454500a889b88d1da5730a2022-12-21T18:09:45ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492016-01-0119332332610.4103/0972-2327.179982Vasculitic neuropathy in elderly: A study from a tertiary care university hospital in South IndiaAnish LawrenceMadhu NagappaAnita MahadevanArun B TalyObjective: To describe clinical, electrophysiological, and histopathological profile of vasculitic neuropathy in elderly subjects aged 65 years or more. Design: Retrospective chart review. Setting: Departments of Neurology and Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India. Patients and Methods: Elderly subjects, diagnosed vasculitic neuropathy by nerve biopsy over one decade, were studied. Results: The cohort consisted of 46 subjects. Symptom duration was 21.54 ± 33.53 months. Onset was chronic in majority (82.6%). Key features included paresthesias (89%), weakness (80%), sensory loss (70%), wasting (63%), and relapsing-remitting course (6.5%). Most Common clinico-electrophysiological patterns were distal symmetrical sensorimotor polyneuropathy - 19, mononeuritis multiplex - 9, and asymmetric sensorimotor neuropathy - 10. Diagnosis of vasculitis was not suspected before biopsy in 31 (67.3%). Nerve biopsy revealed definite vasculitis - 12, probable - 10, and possible - 24. Treatment included immunomodulatory agents (41), symptomatic medications only (9), and antiretroviral therapy (1). Twenty-four patients were followed up for mean period of 6.5 months. Outcome at last follow-up was improved (13), unchanged (8), and worsened (3). Conclusion: Vasculitis is an important, treatable cause of neuropathy in elderly. Nerve biopsy should be used judiciously for early diagnosis and appropriate treatment.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=3;spage=323;epage=326;aulast=LawrenceElderly neuropathynerve biopsyvasculitic neuropathy |
| spellingShingle | Anish Lawrence Madhu Nagappa Anita Mahadevan Arun B Taly Vasculitic neuropathy in elderly: A study from a tertiary care university hospital in South India Annals of Indian Academy of Neurology Elderly neuropathy nerve biopsy vasculitic neuropathy |
| title | Vasculitic neuropathy in elderly: A study from a tertiary care university hospital in South India |
| title_full | Vasculitic neuropathy in elderly: A study from a tertiary care university hospital in South India |
| title_fullStr | Vasculitic neuropathy in elderly: A study from a tertiary care university hospital in South India |
| title_full_unstemmed | Vasculitic neuropathy in elderly: A study from a tertiary care university hospital in South India |
| title_short | Vasculitic neuropathy in elderly: A study from a tertiary care university hospital in South India |
| title_sort | vasculitic neuropathy in elderly a study from a tertiary care university hospital in south india |
| topic | Elderly neuropathy nerve biopsy vasculitic neuropathy |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=3;spage=323;epage=326;aulast=Lawrence |
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