Colorectal cancer and gut microbiota studies in China
ABSTRACTColorectal cancer (CRC) is the third most common malignant tumor worldwide. The incidence and mortality rates of CRC have been increasing in China, possibly due to economic development, lifestyle, and dietary changes. Evidence suggests that gut microbiota plays an essential role in the tumor...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2236364 |
| _version_ | 1797236645059100672 |
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| author | Zikai Wang Wanyue Dan Nana Zhang Jingyuan Fang Yunsheng Yang |
| author_facet | Zikai Wang Wanyue Dan Nana Zhang Jingyuan Fang Yunsheng Yang |
| author_sort | Zikai Wang |
| collection | DOAJ |
| description | ABSTRACTColorectal cancer (CRC) is the third most common malignant tumor worldwide. The incidence and mortality rates of CRC have been increasing in China, possibly due to economic development, lifestyle, and dietary changes. Evidence suggests that gut microbiota plays an essential role in the tumorigenesis of CRC. Gut dysbiosis, specific pathogenic microbes, metabolites, virulence factors, and microbial carcinogenic mechanisms contribute to the initiation and progression of CRC. Gut microbiota biomarkers have potential translational applications in CRC screening and early diagnosis. Gut microbiota-related interventions could improve anti-tumor therapy’s efficacy and severe intestinal toxic effects. Chinese researchers have made many achievements in the relationship between gut microbiota and CRC, although some challenges remain. This review summarizes the current evidence from China on the role of gut microbiota in CRC, mainly including the gut microbiota characteristics, especially Fusobacterium nucleatum and Parvimonas micra, which have been identified to be enriched in CRC patients; microbial pathogens such as F. nucleatum and enterotoxigenic Bacteroides fragilis, and P. micra, which Chinese scientists have extensively studied; diagnostic biomarkers especially F. nucleatum; therapeutic effects, including microecological agents represented by certain Lactobacillus strains, fecal microbiota transplantation, and traditional Chinese medicines such as Berberine and Curcumin. More efforts should be focused on exploring the underlying mechanisms of microbial pathogenesis of CRC and providing novel gut microbiota-related therapeutic and preventive strategies. |
| first_indexed | 2024-03-11T14:19:53Z |
| format | Article |
| id | doaj.art-4dd45183219f48cba35ab1906cae9004 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:08Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-4dd45183219f48cba35ab1906cae90042024-03-28T22:38:21ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2236364Colorectal cancer and gut microbiota studies in ChinaZikai Wang0Wanyue Dan1Nana Zhang2Jingyuan Fang3Yunsheng Yang4Microbiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaDivision of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMicrobiota Division, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, ChinaABSTRACTColorectal cancer (CRC) is the third most common malignant tumor worldwide. The incidence and mortality rates of CRC have been increasing in China, possibly due to economic development, lifestyle, and dietary changes. Evidence suggests that gut microbiota plays an essential role in the tumorigenesis of CRC. Gut dysbiosis, specific pathogenic microbes, metabolites, virulence factors, and microbial carcinogenic mechanisms contribute to the initiation and progression of CRC. Gut microbiota biomarkers have potential translational applications in CRC screening and early diagnosis. Gut microbiota-related interventions could improve anti-tumor therapy’s efficacy and severe intestinal toxic effects. Chinese researchers have made many achievements in the relationship between gut microbiota and CRC, although some challenges remain. This review summarizes the current evidence from China on the role of gut microbiota in CRC, mainly including the gut microbiota characteristics, especially Fusobacterium nucleatum and Parvimonas micra, which have been identified to be enriched in CRC patients; microbial pathogens such as F. nucleatum and enterotoxigenic Bacteroides fragilis, and P. micra, which Chinese scientists have extensively studied; diagnostic biomarkers especially F. nucleatum; therapeutic effects, including microecological agents represented by certain Lactobacillus strains, fecal microbiota transplantation, and traditional Chinese medicines such as Berberine and Curcumin. More efforts should be focused on exploring the underlying mechanisms of microbial pathogenesis of CRC and providing novel gut microbiota-related therapeutic and preventive strategies.https://www.tandfonline.com/doi/10.1080/19490976.2023.2236364Gut microbiotacolorectal cancermicrobial carcinogenesismicrobial biomarkersanti-tumor therapymicrobiota interventions |
| spellingShingle | Zikai Wang Wanyue Dan Nana Zhang Jingyuan Fang Yunsheng Yang Colorectal cancer and gut microbiota studies in China Gut Microbes Gut microbiota colorectal cancer microbial carcinogenesis microbial biomarkers anti-tumor therapy microbiota interventions |
| title | Colorectal cancer and gut microbiota studies in China |
| title_full | Colorectal cancer and gut microbiota studies in China |
| title_fullStr | Colorectal cancer and gut microbiota studies in China |
| title_full_unstemmed | Colorectal cancer and gut microbiota studies in China |
| title_short | Colorectal cancer and gut microbiota studies in China |
| title_sort | colorectal cancer and gut microbiota studies in china |
| topic | Gut microbiota colorectal cancer microbial carcinogenesis microbial biomarkers anti-tumor therapy microbiota interventions |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2236364 |
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