Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis
For traditional artificial dermises, a waiting period of approximately three weeks is required after the first implantation before they are adequately vascularized. The objective of this retrospective case series was to investigate whether full-thickness skin defects, requiring surgical reconstructi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320422000700 |
| _version_ | 1811293760217153536 |
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| author | Ryushiro Sugimoto Hiroki Yamanaka Itaru Tsuge Yasuhiro Katayama Motoki Katsube Michiharu Sakamoto Naoki Morimoto |
| author_facet | Ryushiro Sugimoto Hiroki Yamanaka Itaru Tsuge Yasuhiro Katayama Motoki Katsube Michiharu Sakamoto Naoki Morimoto |
| author_sort | Ryushiro Sugimoto |
| collection | DOAJ |
| description | For traditional artificial dermises, a waiting period of approximately three weeks is required after the first implantation before they are adequately vascularized. The objective of this retrospective case series was to investigate whether full-thickness skin defects, requiring surgical reconstruction, could be successfully treated by implantation of a basic fibroblast growth factor (bFGF)-impregnated artificial dermis and secondary skin grafting with a shorter waiting period. Between January 2019 and January 2021, 19 skin defects in 14 patients (7 male and 7 female) were treated with two-stage skin grafting using bFGF-impregnated collagen-gelatin sponge (CGS). All of them were included in this case series, and the waiting period for skin grafting, success rate of skin grafting, infection during the waiting period, and scar quality 6–12 months postoperatively were retrospectively investigated. As a result, all skin grafting surgeries were successfully performed with a waiting period of 13.3 ± 4.3 days. Infection during the waiting period was observed in three lesions (15.8%); however, all infections were controllable. Postoperative scar quality was acceptable (Vancouver Scar Scale score range, 1–8). In conclusion, compared to traditional artificial dermises, bFGF-impregnated CGSs have the potential to shorten the waiting period without decreasing the success rate of skin grafting. Further studies are required to confirm this finding. |
| first_indexed | 2024-04-13T05:07:22Z |
| format | Article |
| id | doaj.art-4dd4f6738c1443a58564d3b81c22f784 |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-04-13T05:07:22Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-4dd4f6738c1443a58564d3b81c22f7842022-12-22T03:01:09ZengElsevierRegenerative Therapy2352-32042022-12-0121258262Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermisRyushiro Sugimoto0Hiroki Yamanaka1Itaru Tsuge2Yasuhiro Katayama3Motoki Katsube4Michiharu Sakamoto5Naoki Morimoto6Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanCorresponding author.; Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto 606-8507, JapanFor traditional artificial dermises, a waiting period of approximately three weeks is required after the first implantation before they are adequately vascularized. The objective of this retrospective case series was to investigate whether full-thickness skin defects, requiring surgical reconstruction, could be successfully treated by implantation of a basic fibroblast growth factor (bFGF)-impregnated artificial dermis and secondary skin grafting with a shorter waiting period. Between January 2019 and January 2021, 19 skin defects in 14 patients (7 male and 7 female) were treated with two-stage skin grafting using bFGF-impregnated collagen-gelatin sponge (CGS). All of them were included in this case series, and the waiting period for skin grafting, success rate of skin grafting, infection during the waiting period, and scar quality 6–12 months postoperatively were retrospectively investigated. As a result, all skin grafting surgeries were successfully performed with a waiting period of 13.3 ± 4.3 days. Infection during the waiting period was observed in three lesions (15.8%); however, all infections were controllable. Postoperative scar quality was acceptable (Vancouver Scar Scale score range, 1–8). In conclusion, compared to traditional artificial dermises, bFGF-impregnated CGSs have the potential to shorten the waiting period without decreasing the success rate of skin grafting. Further studies are required to confirm this finding.http://www.sciencedirect.com/science/article/pii/S2352320422000700Artificial dermisBasic fibroblast growth factorTwo-stage skin graftingWaiting period |
| spellingShingle | Ryushiro Sugimoto Hiroki Yamanaka Itaru Tsuge Yasuhiro Katayama Motoki Katsube Michiharu Sakamoto Naoki Morimoto Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis Regenerative Therapy Artificial dermis Basic fibroblast growth factor Two-stage skin grafting Waiting period |
| title | Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis |
| title_full | Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis |
| title_fullStr | Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis |
| title_full_unstemmed | Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis |
| title_short | Two-stage skin grafting using a basic fibroblast growth factor-impregnated artificial dermis |
| title_sort | two stage skin grafting using a basic fibroblast growth factor impregnated artificial dermis |
| topic | Artificial dermis Basic fibroblast growth factor Two-stage skin grafting Waiting period |
| url | http://www.sciencedirect.com/science/article/pii/S2352320422000700 |
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