A Combination Of Amoxicillian And Clavulanic Acid In The Treatment Of Impetigo In Children
Amoxicillin plus clavulanic acid (ACA) a combination of potentially effective antibiotic against beta-lactamase producing bacteria was compared with that of amoxicillin, erythomycin and co-trimoxazole in an open label, randomized trial in 100 children with mild to severe impetigo. 22% chi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
1998-01-01
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| Series: | Indian Journal of Dermatology |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=1998;volume=43;issue=1;spage=7;epage=9;aulast=P;type=0 |
| Summary: | Amoxicillin plus clavulanic acid (ACA) a combination of potentially effective antibiotic against beta-lactamase producing bacteria was compared with that of amoxicillin, erythomycin and co-trimoxazole in an open label, randomized trial in 100 children with mild to severe impetigo. 22% children had mild, 25% had moderate and 53% children had severe impetigo. Pure growth of S. aureus was isolated in 68% children, S.pyogenes in 26% and both staphyto and streptococci in 6% children. In mild to moderate infection 100% children receiving ACA were cured clinically after first week, whereas 7 out of 15(46.6%) children in amoxicillin group, 7 out of 13(53.1%) children in erythromycin group and 4 out 12 (33.3%) children in co-trimoxazole group showed clinical cure after first week. In severe impetigo 46.1% children receiving ACA, 20% children in amoxicillin group, 16.6% children inerythromycin group and 7.6% in co-trimoxazole group showed clinical cure on therapy after one week. ACA was well tolerated in children. |
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| ISSN: | 0019-5154 1998-3611 |