Dual Role of Indoles Derived From Intestinal Microbiota on Human Health
Endogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and exhibit a range of biological activities. Recent studies indicate that indoles contribute to maintaining the biological bar...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.903526/full |
| _version_ | 1811337642369875968 |
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| author | Xuewei Ye Xuewei Ye Haiyi Li Komal Anjum Xinye Zhong Shuping Miao Guowan Zheng Guowan Zheng Wei Liu Lanjuan Li |
| author_facet | Xuewei Ye Xuewei Ye Haiyi Li Komal Anjum Xinye Zhong Shuping Miao Guowan Zheng Guowan Zheng Wei Liu Lanjuan Li |
| author_sort | Xuewei Ye |
| collection | DOAJ |
| description | Endogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and exhibit a range of biological activities. Recent studies indicate that indoles contribute to maintaining the biological barrier of the human intestine, which exert the anti-inflammatory activities mainly through activating AhR and PXR receptors to affect the immune system’s function, significantly improving intestinal health (inflammatory bowel disease, hemorrhagic colitis, colorectal cancer) and further promote human health (diabetes mellitus, central system inflammation, and vascular regulation). However, the revealed toxic influences cannot be ignored. Indoxyl sulfate, an indole derivative, performs nephrotoxicity and cardiovascular toxicity. We addressed the interaction between indoles and intestinal microbiota and the indoles’ effects on human health as double-edged swords. This review provides scientific bases for the correlation of indoles with diseases moreover highlights several directions for subsequent indoles-related studies. |
| first_indexed | 2024-04-13T17:57:49Z |
| format | Article |
| id | doaj.art-4dd74137470d41e594e81695eab654bb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T17:57:49Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4dd74137470d41e594e81695eab654bb2022-12-22T02:36:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.903526903526Dual Role of Indoles Derived From Intestinal Microbiota on Human HealthXuewei Ye0Xuewei Ye1Haiyi Li2Komal Anjum3Xinye Zhong4Shuping Miao5Guowan Zheng6Guowan Zheng7Wei Liu8Lanjuan Li9State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, ChinaDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaDepartment of Medicine and pharmacy, Ocean University of China, Qingdao, ChinaDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaDepartment of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, ChinaKey Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, ChinaOtolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaInstitute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, ChinaEndogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and exhibit a range of biological activities. Recent studies indicate that indoles contribute to maintaining the biological barrier of the human intestine, which exert the anti-inflammatory activities mainly through activating AhR and PXR receptors to affect the immune system’s function, significantly improving intestinal health (inflammatory bowel disease, hemorrhagic colitis, colorectal cancer) and further promote human health (diabetes mellitus, central system inflammation, and vascular regulation). However, the revealed toxic influences cannot be ignored. Indoxyl sulfate, an indole derivative, performs nephrotoxicity and cardiovascular toxicity. We addressed the interaction between indoles and intestinal microbiota and the indoles’ effects on human health as double-edged swords. This review provides scientific bases for the correlation of indoles with diseases moreover highlights several directions for subsequent indoles-related studies.https://www.frontiersin.org/articles/10.3389/fimmu.2022.903526/fullindoleinflammationintestinal floraindoxyl sulfatedual role |
| spellingShingle | Xuewei Ye Xuewei Ye Haiyi Li Komal Anjum Xinye Zhong Shuping Miao Guowan Zheng Guowan Zheng Wei Liu Lanjuan Li Dual Role of Indoles Derived From Intestinal Microbiota on Human Health Frontiers in Immunology indole inflammation intestinal flora indoxyl sulfate dual role |
| title | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
| title_full | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
| title_fullStr | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
| title_full_unstemmed | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
| title_short | Dual Role of Indoles Derived From Intestinal Microbiota on Human Health |
| title_sort | dual role of indoles derived from intestinal microbiota on human health |
| topic | indole inflammation intestinal flora indoxyl sulfate dual role |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.903526/full |
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