The peculiar challenge of bringing CAR-T cells into the brain: Perspectives in the clinical application to the treatment of pediatric central nervous system tumors

The peculiar challenge of bringing CAR-T cells into the brain: Perspectives in the clinical application to the treatment of pediatric central nervous system tumors

Childhood malignant brain tumors remain a significant cause of death in the pediatric population, despite the use of aggressive multimodal treatments. New therapeutic approaches are urgently needed for these patients in order to improve prognosis, while reducing side effects and long-term sequelae o...

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Bibliographic Details
Main Authors: Giada Del Baldo, Francesca Del Bufalo, Claudia Pinacchio, Andrea Carai, Concetta Quintarelli, Biagio De Angelis, Pietro Merli, Antonella Cacchione, Franco Locatelli, Angela Mastronuzzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
pediatric brain tumors
CAR-T cells
blood-brain barrier
glymphatic system
neurotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1142597/full

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