Effect of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide in combination with antibacterial drugs against Klebsiella pneumoniae
Abstract Klebsiella pneumoniae is a species of Gram-negative bacteria related to a wide range of infections and high rates of drug resistance. The combined use of antibacterial agents is one of the strategies that has been analyzed in recent years as part of the alternatives in the treatment of drug...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Ciências
2023-03-01
|
| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000300701&lng=en&tlng=en |
| _version_ | 1797871138312814592 |
|---|---|
| author | LAÍSA V. CORDEIRO HELIVALDO D.S. SOUZA ALESON P. SOUSA FRANCISCO P. DE ANDRADE JÚNIOR PEDRO T.R. DE FIGUEIREDO RAFAEL F. DE OLIVEIRA PETRÔNIO F. DE ATHAYDE FILHO ABRAHÃO A. OLIVEIRA-FILHO EDELTRUDES DE O. LIMA |
| author_facet | LAÍSA V. CORDEIRO HELIVALDO D.S. SOUZA ALESON P. SOUSA FRANCISCO P. DE ANDRADE JÚNIOR PEDRO T.R. DE FIGUEIREDO RAFAEL F. DE OLIVEIRA PETRÔNIO F. DE ATHAYDE FILHO ABRAHÃO A. OLIVEIRA-FILHO EDELTRUDES DE O. LIMA |
| author_sort | LAÍSA V. CORDEIRO |
| collection | DOAJ |
| description | Abstract Klebsiella pneumoniae is a species of Gram-negative bacteria related to a wide range of infections and high rates of drug resistance. The combined use of antibacterial agents is one of the strategies that has been analyzed in recent years as part of the alternatives in the treatment of drug-resistant infections. Recently, the antibacterial activity of of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide has been demonstrated against K. pneumoniae, also indicating that this acetamide did not show significant cytotoxic potential in preliminary tests. Thus, it becomes an interesting substance for future studies that explore its antimicrobial capacity, including investigating its association with antibacterial drugs. Based on this, this research aimed to analyze the effects of the association of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide (CFA) with ciprofloxacin, cefepime, ceftazidime, meropenem and imipenem against K. pneumoniae strains. The results showed additivity when the substance was combined with ciprofloxacin and cefepime, indifference when associated with ceftazidime and synergistic effect when combined with meropenem and imipenem. Thus, the acetamide was able to optimize the effects of antibacterial drugs, reducing the concentrations necessary to cause bacterial death. These data indicate a potential future clinical use of these combinations, and further studies are needed to analyze this viability. |
| first_indexed | 2024-04-10T00:39:27Z |
| format | Article |
| id | doaj.art-4dd8ac7471314774b77b983d3b7be47f |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-10T00:39:27Z |
| publishDate | 2023-03-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-4dd8ac7471314774b77b983d3b7be47f2023-03-14T07:32:57ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902023-03-0195210.1590/0001-3765202320210141Effect of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide in combination with antibacterial drugs against Klebsiella pneumoniaeLAÍSA V. CORDEIROhttps://orcid.org/0000-0002-8884-7331HELIVALDO D.S. SOUZAhttps://orcid.org/0000-0002-1708-4066ALESON P. SOUSAhttps://orcid.org/0000-0002-3430-477XFRANCISCO P. DE ANDRADE JÚNIORhttps://orcid.org/0000-0003-0681-8439PEDRO T.R. DE FIGUEIREDOhttps://orcid.org/0000-0001-6132-6248RAFAEL F. DE OLIVEIRAhttps://orcid.org/0000-0002-1654-9052PETRÔNIO F. DE ATHAYDE FILHOhttps://orcid.org/0000-0003-0982-8261ABRAHÃO A. OLIVEIRA-FILHOhttps://orcid.org/0000-0002-7466-9933EDELTRUDES DE O. LIMAhttps://orcid.org/0000-0002-9547-0886Abstract Klebsiella pneumoniae is a species of Gram-negative bacteria related to a wide range of infections and high rates of drug resistance. The combined use of antibacterial agents is one of the strategies that has been analyzed in recent years as part of the alternatives in the treatment of drug-resistant infections. Recently, the antibacterial activity of of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide has been demonstrated against K. pneumoniae, also indicating that this acetamide did not show significant cytotoxic potential in preliminary tests. Thus, it becomes an interesting substance for future studies that explore its antimicrobial capacity, including investigating its association with antibacterial drugs. Based on this, this research aimed to analyze the effects of the association of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide (CFA) with ciprofloxacin, cefepime, ceftazidime, meropenem and imipenem against K. pneumoniae strains. The results showed additivity when the substance was combined with ciprofloxacin and cefepime, indifference when associated with ceftazidime and synergistic effect when combined with meropenem and imipenem. Thus, the acetamide was able to optimize the effects of antibacterial drugs, reducing the concentrations necessary to cause bacterial death. These data indicate a potential future clinical use of these combinations, and further studies are needed to analyze this viability.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000300701&lng=en&tlng=enacetamidedrug associationKlebsiella pneumoniae2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide |
| spellingShingle | LAÍSA V. CORDEIRO HELIVALDO D.S. SOUZA ALESON P. SOUSA FRANCISCO P. DE ANDRADE JÚNIOR PEDRO T.R. DE FIGUEIREDO RAFAEL F. DE OLIVEIRA PETRÔNIO F. DE ATHAYDE FILHO ABRAHÃO A. OLIVEIRA-FILHO EDELTRUDES DE O. LIMA Effect of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide in combination with antibacterial drugs against Klebsiella pneumoniae Anais da Academia Brasileira de Ciências acetamide drug association Klebsiella pneumoniae 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide |
| title | Effect of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide in combination with antibacterial drugs against Klebsiella pneumoniae |
| title_full | Effect of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide in combination with antibacterial drugs against Klebsiella pneumoniae |
| title_fullStr | Effect of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide in combination with antibacterial drugs against Klebsiella pneumoniae |
| title_full_unstemmed | Effect of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide in combination with antibacterial drugs against Klebsiella pneumoniae |
| title_short | Effect of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide in combination with antibacterial drugs against Klebsiella pneumoniae |
| title_sort | effect of 2 chloro n 4 fluoro 3 nitrophenyl acetamide in combination with antibacterial drugs against klebsiella pneumoniae |
| topic | acetamide drug association Klebsiella pneumoniae 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000300701&lng=en&tlng=en |
| work_keys_str_mv | AT laisavcordeiro effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae AT helivaldodssouza effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae AT alesonpsousa effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae AT franciscopdeandradejunior effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae AT pedrotrdefigueiredo effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae AT rafaelfdeoliveira effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae AT petroniofdeathaydefilho effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae AT abrahaoaoliveirafilho effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae AT edeltrudesdeolima effectof2chloron4fluoro3nitrophenylacetamideincombinationwithantibacterialdrugsagainstklebsiellapneumoniae |