The value of CT findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesions
Abstract Background The study aimed to explore the value of CT findings and inflammatory indicators in differentiating benign and malignant gallbladder polypoid lesions before surgery. Methods The study comprised a total of 113 pathologically confirmed gallbladder polypoid lesions with a maximum dia...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-023-02941-x |
| _version_ | 1797864489870163968 |
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| author | Juan Zhang Yuxian Wu Yayuan Feng Jiazhao Fu Ningyang Jia |
| author_facet | Juan Zhang Yuxian Wu Yayuan Feng Jiazhao Fu Ningyang Jia |
| author_sort | Juan Zhang |
| collection | DOAJ |
| description | Abstract Background The study aimed to explore the value of CT findings and inflammatory indicators in differentiating benign and malignant gallbladder polypoid lesions before surgery. Methods The study comprised a total of 113 pathologically confirmed gallbladder polypoid lesions with a maximum diameter ≥ 1 cm (68 benign and 45 malignant), all of which were enhanced CT-scanned within 1 month before surgery. The CT findings and inflammatory indicators of the patients were analyzed by univariate and multivariate logistic regression analysis to identify independent predictors of gallbladder polypoid lesions, and then a nomogram distinguishing benign and malignant gallbladder polypoid lesions was developed by combining these characteristics. The receiver operating characteristic (ROC) curve and decision curve were plotted to assess the performance of the nomogram. Results Base status of the lesion (p < 0.001), plain CT value (p < 0.001), neutrophil–lymphocyte ratio (NLR) (p = 0.041), and monocyte-lymphocyte ratio (MLR) (p = 0.022) were independent predictors of malignant polypoid lesions of the gallbladder. The nomogram model established by incorporating the above factors had good performance in differentiating and predicting benign and malignant gallbladder polypoid lesions (AUC = 0.964), with sensitivity and specificity of 82.4% and 97.8%, respectively. The DCA demonstrated the important clinical utility of our nomogram. Conclusion CT findings combined with inflammatory indicators can effectively differentiate benign and malignant gallbladder polypoid lesions before surgery, which is valuable for clinical decision-making. |
| first_indexed | 2024-04-09T22:53:47Z |
| format | Article |
| id | doaj.art-4dd8ee81d3184bb99f28c8605bae7e74 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-09T22:53:47Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-4dd8ee81d3184bb99f28c8605bae7e742023-03-22T11:24:10ZengBMCWorld Journal of Surgical Oncology1477-78192023-02-0121111010.1186/s12957-023-02941-xThe value of CT findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesionsJuan Zhang0Yuxian Wu1Yayuan Feng2Jiazhao Fu3Ningyang Jia4Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical UniversityDepartment of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical UniversityDepartment of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical UniversityDepartment of Organ Transplantation, Changhai Hospital, First Affiliated Hospital of Naval Medical UniversityDepartment of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical UniversityAbstract Background The study aimed to explore the value of CT findings and inflammatory indicators in differentiating benign and malignant gallbladder polypoid lesions before surgery. Methods The study comprised a total of 113 pathologically confirmed gallbladder polypoid lesions with a maximum diameter ≥ 1 cm (68 benign and 45 malignant), all of which were enhanced CT-scanned within 1 month before surgery. The CT findings and inflammatory indicators of the patients were analyzed by univariate and multivariate logistic regression analysis to identify independent predictors of gallbladder polypoid lesions, and then a nomogram distinguishing benign and malignant gallbladder polypoid lesions was developed by combining these characteristics. The receiver operating characteristic (ROC) curve and decision curve were plotted to assess the performance of the nomogram. Results Base status of the lesion (p < 0.001), plain CT value (p < 0.001), neutrophil–lymphocyte ratio (NLR) (p = 0.041), and monocyte-lymphocyte ratio (MLR) (p = 0.022) were independent predictors of malignant polypoid lesions of the gallbladder. The nomogram model established by incorporating the above factors had good performance in differentiating and predicting benign and malignant gallbladder polypoid lesions (AUC = 0.964), with sensitivity and specificity of 82.4% and 97.8%, respectively. The DCA demonstrated the important clinical utility of our nomogram. Conclusion CT findings combined with inflammatory indicators can effectively differentiate benign and malignant gallbladder polypoid lesions before surgery, which is valuable for clinical decision-making.https://doi.org/10.1186/s12957-023-02941-xGallbladder polypoidsComputed tomographyInflammatory indicatorNomogram |
| spellingShingle | Juan Zhang Yuxian Wu Yayuan Feng Jiazhao Fu Ningyang Jia The value of CT findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesions World Journal of Surgical Oncology Gallbladder polypoids Computed tomography Inflammatory indicator Nomogram |
| title | The value of CT findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesions |
| title_full | The value of CT findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesions |
| title_fullStr | The value of CT findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesions |
| title_full_unstemmed | The value of CT findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesions |
| title_short | The value of CT findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesions |
| title_sort | value of ct findings combined with inflammatory indicators for preoperative differentiation of benign and malignant gallbladder polypoid lesions |
| topic | Gallbladder polypoids Computed tomography Inflammatory indicator Nomogram |
| url | https://doi.org/10.1186/s12957-023-02941-x |
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