Design and rationale of the Post-Intensive Care Syndrome – paediatrics (PICS-p) Longitudinal Cohort Study
Introduction As paediatric intensive care unit (PICU) mortality declines, there is growing recognition of the morbidity experienced by children surviving critical illness and their families. A comprehensive understanding of the adverse physical, cognitive, emotional and social sequelae common to PIC...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-02-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/2/e084445.full |
| _version_ | 1827149450879959040 |
|---|---|
| author | David Wypij Gillian Colville Joseph C Manning Martha A Q Curley R Scott Watson Elizabeth Y Killien Laura Beth Kalvas Mallory A Perry-Eaddy Amy M Cassidy Erica B Miller Mritika Talukder Neethi P Pinto Janet E Rennick Lisa A Asaro |
| author_facet | David Wypij Gillian Colville Joseph C Manning Martha A Q Curley R Scott Watson Elizabeth Y Killien Laura Beth Kalvas Mallory A Perry-Eaddy Amy M Cassidy Erica B Miller Mritika Talukder Neethi P Pinto Janet E Rennick Lisa A Asaro |
| author_sort | David Wypij |
| collection | DOAJ |
| description | Introduction As paediatric intensive care unit (PICU) mortality declines, there is growing recognition of the morbidity experienced by children surviving critical illness and their families. A comprehensive understanding of the adverse physical, cognitive, emotional and social sequelae common to PICU survivors is limited, however, and the trajectory of recovery and risk factors for morbidity remain unknown.Methods and analysis The Post-Intensive Care Syndrome – paediatrics Longitudinal Cohort Study will evaluate child and family outcomes over 2 years following PICU discharge and identify child and clinical factors associated with impaired outcomes. We will enrol 750 children from 30 US PICUs during their first PICU hospitalisation, including 500 case participants experiencing ≥3 days of intensive care that include critical care therapies (eg, mechanical ventilation, vasoactive infusions) and 250 age-matched, sex-matched and medical complexity-matched control participants experiencing a single night in the PICU with no intensive care therapies. Children, parents and siblings will complete surveys about health-related quality of life, physical function, cognitive status, emotional health and peer and family relationships at multiple time points from baseline recall through 2 years post-PICU discharge. We will compare outcomes and recovery trajectories of case participants to control participants, identify risk factors associated with poor outcomes and determine the emotional and social health consequences of paediatric critical illness on parents and siblings.Ethics and dissemination This study has received ethical approval from the University of Pennsylvania Institutional Review Board (protocol #843844). Our overall objective is to characterise the ongoing impact of paediatric critical illness to guide development of interventions that optimise outcomes among children surviving critical illness and their families. Findings will be presented at key disciplinary meetings and in peer-reviewed publications at fixed data points. Published manuscripts will be added to our public study website to ensure findings are available to families, clinicians and researchers.Trials registration number NCT04967365. |
| first_indexed | 2024-03-07T21:46:14Z |
| format | Article |
| id | doaj.art-4ddb82bf88924d608ead0a64abbaea68 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-03-20T21:18:23Z |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-4ddb82bf88924d608ead0a64abbaea682024-08-13T01:55:10ZengBMJ Publishing GroupBMJ Open2044-60552024-02-0114210.1136/bmjopen-2024-084445Design and rationale of the Post-Intensive Care Syndrome – paediatrics (PICS-p) Longitudinal Cohort StudyDavid Wypij0Gillian Colville1Joseph C Manning2Martha A Q Curley3R Scott Watson4Elizabeth Y Killien5Laura Beth Kalvas6Mallory A Perry-Eaddy7Amy M Cassidy8Erica B Miller9Mritika Talukder10Neethi P Pinto11Janet E Rennick12Lisa A Asaro13Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USASt George`s University of London, London, UKSchool of Healthcare, University of Leicester, Leicester, UKSchool of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USAUniversity of Washington School of Medicine, Seattle, Washington, USASeattle Children`s Research Institute, Seattle, Washington, USASchool of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USASchool of Nursing, University of Connecticut, Storrs, Connecticut, USASchool of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USASeattle Children`s Research Institute, Seattle, Washington, USASchool of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USAThe Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USAMcGill University Health Centre, Montreal Children`s Hospital, Montreal, Québec, CanadaBoston Children`s Hospital, Boston, Massachusetts, USAIntroduction As paediatric intensive care unit (PICU) mortality declines, there is growing recognition of the morbidity experienced by children surviving critical illness and their families. A comprehensive understanding of the adverse physical, cognitive, emotional and social sequelae common to PICU survivors is limited, however, and the trajectory of recovery and risk factors for morbidity remain unknown.Methods and analysis The Post-Intensive Care Syndrome – paediatrics Longitudinal Cohort Study will evaluate child and family outcomes over 2 years following PICU discharge and identify child and clinical factors associated with impaired outcomes. We will enrol 750 children from 30 US PICUs during their first PICU hospitalisation, including 500 case participants experiencing ≥3 days of intensive care that include critical care therapies (eg, mechanical ventilation, vasoactive infusions) and 250 age-matched, sex-matched and medical complexity-matched control participants experiencing a single night in the PICU with no intensive care therapies. Children, parents and siblings will complete surveys about health-related quality of life, physical function, cognitive status, emotional health and peer and family relationships at multiple time points from baseline recall through 2 years post-PICU discharge. We will compare outcomes and recovery trajectories of case participants to control participants, identify risk factors associated with poor outcomes and determine the emotional and social health consequences of paediatric critical illness on parents and siblings.Ethics and dissemination This study has received ethical approval from the University of Pennsylvania Institutional Review Board (protocol #843844). Our overall objective is to characterise the ongoing impact of paediatric critical illness to guide development of interventions that optimise outcomes among children surviving critical illness and their families. Findings will be presented at key disciplinary meetings and in peer-reviewed publications at fixed data points. Published manuscripts will be added to our public study website to ensure findings are available to families, clinicians and researchers.Trials registration number NCT04967365.https://bmjopen.bmj.com/content/14/2/e084445.full |
| spellingShingle | David Wypij Gillian Colville Joseph C Manning Martha A Q Curley R Scott Watson Elizabeth Y Killien Laura Beth Kalvas Mallory A Perry-Eaddy Amy M Cassidy Erica B Miller Mritika Talukder Neethi P Pinto Janet E Rennick Lisa A Asaro Design and rationale of the Post-Intensive Care Syndrome – paediatrics (PICS-p) Longitudinal Cohort Study BMJ Open |
| title | Design and rationale of the Post-Intensive Care Syndrome – paediatrics (PICS-p) Longitudinal Cohort Study |
| title_full | Design and rationale of the Post-Intensive Care Syndrome – paediatrics (PICS-p) Longitudinal Cohort Study |
| title_fullStr | Design and rationale of the Post-Intensive Care Syndrome – paediatrics (PICS-p) Longitudinal Cohort Study |
| title_full_unstemmed | Design and rationale of the Post-Intensive Care Syndrome – paediatrics (PICS-p) Longitudinal Cohort Study |
| title_short | Design and rationale of the Post-Intensive Care Syndrome – paediatrics (PICS-p) Longitudinal Cohort Study |
| title_sort | design and rationale of the post intensive care syndrome paediatrics pics p longitudinal cohort study |
| url | https://bmjopen.bmj.com/content/14/2/e084445.full |
| work_keys_str_mv | AT davidwypij designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT gilliancolville designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT josephcmanning designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT marthaaqcurley designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT rscottwatson designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT elizabethykillien designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT laurabethkalvas designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT malloryaperryeaddy designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT amymcassidy designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT ericabmiller designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT mritikatalukder designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT neethippinto designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT janeterennick designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy AT lisaaasaro designandrationaleofthepostintensivecaresyndromepaediatricspicsplongitudinalcohortstudy |