Near-infrared and pH responsive molecular machine for controlled encapsulation and release of drugs
It is difficult to form nanoparticles by traditional polymerization methods, using the azobenzene monomer with large hindrance. In this work, distillation precipitation polymerization (DPP) with lowering the monomer content at the beginning and distilling the solvent at a constant speed. Monofunctio...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Polymer Testing |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0142941822001556 |
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| author | Xiaotao Wang Zhuofan Chen Yebin Yang Huiling Guo Yingkui Yang Chak-Yin Tang Xuefeng Li Wing-Cheung Law |
| author_facet | Xiaotao Wang Zhuofan Chen Yebin Yang Huiling Guo Yingkui Yang Chak-Yin Tang Xuefeng Li Wing-Cheung Law |
| author_sort | Xiaotao Wang |
| collection | DOAJ |
| description | It is difficult to form nanoparticles by traditional polymerization methods, using the azobenzene monomer with large hindrance. In this work, distillation precipitation polymerization (DPP) with lowering the monomer content at the beginning and distilling the solvent at a constant speed. Monofunctional 6-(4-methoxy-4′-oxygen-azobenzene) hexyl methacrylate (Azo) as a photo-responsive monomer and methacrylic acid (MAA) as a pH responsive monomer, were used to synthesize UCNPs@SiO2@PAzo/MAA nanoparticles. After the SiO2 was etched, UCNPs@PAzo/MAA nanocapsules (NCs) were formed. The trans isomer in the PAzo shell is converted into cis under 980 nm near-infrared (NIR) irradiation, leading to a variation of size and hydrophilicity of the nanocapsules. Controlled drug loading (∼17.5%) could be performed using UV irradiation, in which the pendant Azo groups have an cis “open” state and larger hydrophilicity. Under weak acid and NIR irradiation, the pendant Azo group with constant isomerization is like a “molecular impeller” agitator and the cumulative release rate of the doxorubicin (DOX) reaches 67.88%. Furthermore, UCNPs@PAzo/MAA nanocapsules were applied to the intracellular environment, and the cytotoxicity was studied. The cell images and cytotoxicity studies showed that the drug could be efficiently delivered to the nucleus by the UCNPs@PAzo/MAA nanocapsules in a controlled manner. |
| first_indexed | 2024-04-12T14:04:07Z |
| format | Article |
| id | doaj.art-4ddddb4622e145d78f0cd144e7025273 |
| institution | Directory Open Access Journal |
| issn | 0142-9418 |
| language | English |
| last_indexed | 2024-04-12T14:04:07Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Polymer Testing |
| spelling | doaj.art-4ddddb4622e145d78f0cd144e70252732022-12-22T03:30:07ZengElsevierPolymer Testing0142-94182022-08-01112107631Near-infrared and pH responsive molecular machine for controlled encapsulation and release of drugsXiaotao Wang0Zhuofan Chen1Yebin Yang2Huiling Guo3Yingkui Yang4Chak-Yin Tang5Xuefeng Li6Wing-Cheung Law7Hubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center for Green Light-weight Materials and Processing, School of Materials Science and Engineering, Hubei University of Technology, Wuhan, 430068, ChinaHubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center for Green Light-weight Materials and Processing, School of Materials Science and Engineering, Hubei University of Technology, Wuhan, 430068, ChinaHubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center for Green Light-weight Materials and Processing, School of Materials Science and Engineering, Hubei University of Technology, Wuhan, 430068, ChinaHubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center for Green Light-weight Materials and Processing, School of Materials Science and Engineering, Hubei University of Technology, Wuhan, 430068, ChinaKey Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, South-Central University for Nationalities, Wuhan, 430074, China; Corresponding author.,Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, ChinaHubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center for Green Light-weight Materials and Processing, School of Materials Science and Engineering, Hubei University of Technology, Wuhan, 430068, China; Corresponding author.,Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China; Corresponding author.It is difficult to form nanoparticles by traditional polymerization methods, using the azobenzene monomer with large hindrance. In this work, distillation precipitation polymerization (DPP) with lowering the monomer content at the beginning and distilling the solvent at a constant speed. Monofunctional 6-(4-methoxy-4′-oxygen-azobenzene) hexyl methacrylate (Azo) as a photo-responsive monomer and methacrylic acid (MAA) as a pH responsive monomer, were used to synthesize UCNPs@SiO2@PAzo/MAA nanoparticles. After the SiO2 was etched, UCNPs@PAzo/MAA nanocapsules (NCs) were formed. The trans isomer in the PAzo shell is converted into cis under 980 nm near-infrared (NIR) irradiation, leading to a variation of size and hydrophilicity of the nanocapsules. Controlled drug loading (∼17.5%) could be performed using UV irradiation, in which the pendant Azo groups have an cis “open” state and larger hydrophilicity. Under weak acid and NIR irradiation, the pendant Azo group with constant isomerization is like a “molecular impeller” agitator and the cumulative release rate of the doxorubicin (DOX) reaches 67.88%. Furthermore, UCNPs@PAzo/MAA nanocapsules were applied to the intracellular environment, and the cytotoxicity was studied. The cell images and cytotoxicity studies showed that the drug could be efficiently delivered to the nucleus by the UCNPs@PAzo/MAA nanocapsules in a controlled manner.http://www.sciencedirect.com/science/article/pii/S0142941822001556UpconversionPhotoisomerizationAzobenzeneControlled releaseDual-responsive |
| spellingShingle | Xiaotao Wang Zhuofan Chen Yebin Yang Huiling Guo Yingkui Yang Chak-Yin Tang Xuefeng Li Wing-Cheung Law Near-infrared and pH responsive molecular machine for controlled encapsulation and release of drugs Polymer Testing Upconversion Photoisomerization Azobenzene Controlled release Dual-responsive |
| title | Near-infrared and pH responsive molecular machine for controlled encapsulation and release of drugs |
| title_full | Near-infrared and pH responsive molecular machine for controlled encapsulation and release of drugs |
| title_fullStr | Near-infrared and pH responsive molecular machine for controlled encapsulation and release of drugs |
| title_full_unstemmed | Near-infrared and pH responsive molecular machine for controlled encapsulation and release of drugs |
| title_short | Near-infrared and pH responsive molecular machine for controlled encapsulation and release of drugs |
| title_sort | near infrared and ph responsive molecular machine for controlled encapsulation and release of drugs |
| topic | Upconversion Photoisomerization Azobenzene Controlled release Dual-responsive |
| url | http://www.sciencedirect.com/science/article/pii/S0142941822001556 |
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