Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes

Genomic Instability Profiles at the Single Cell Level in Mouse Colorectal Cancers of Defined Genotypes

The genomes of many human CRCs have been sequenced, revealing a large number of genetic alterations. However, the molecular mechanisms underlying the accumulation of these alterations are still being debated. In this study, we examined colorectal tumours that developed in mice with <i>Apc<s...

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Bibliographic Details
Main Authors: Vasilis S. Dionellis, Maxim Norkin, Angeliki Karamichali, Giacomo G. Rossetti, Joerg Huelsken, Paloma Ordonez-Moran, Thanos D. Halazonetis
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
colorectal cancer
single cell
genomic instability
exome sequencing
mouse models
cancer drivers
Online Access:https://www.mdpi.com/2072-6694/13/6/1267

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