Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis
Two novel molecular mechanisms with a driver role in pituitary tumorigenesis have been recently identified. They are (a) mutations in the Ubiquitin-Specific Protease 8 (USP8) gene in corticotroph tumors and (b) overexpression of the <i>HMGA1</i> and <i>HMGA2</i> genes in most...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/9/1302 |
| _version_ | 1797708386070953984 |
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| author | Daniela D’Angelo Marco De Martino Claudio Arra Alfredo Fusco |
| author_facet | Daniela D’Angelo Marco De Martino Claudio Arra Alfredo Fusco |
| author_sort | Daniela D’Angelo |
| collection | DOAJ |
| description | Two novel molecular mechanisms with a driver role in pituitary tumorigenesis have been recently identified. They are (a) mutations in the Ubiquitin-Specific Protease 8 (USP8) gene in corticotroph tumors and (b) overexpression of the <i>HMGA1</i> and <i>HMGA2</i> genes in most of the pituitary tumors. Moreover, deregulated expression of the non-coding RNAs has been very frequently observed in this neoplasia. The aim of this review is to better elucidate the role, the mechanisms, and the possible clinical impact of these novel alterations in the development of pituitary neoplasia. |
| first_indexed | 2024-03-12T06:20:42Z |
| format | Article |
| id | doaj.art-4de0f1142d09431f835e75e94e564f74 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:20:42Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4de0f1142d09431f835e75e94e564f742023-09-03T02:14:09ZengMDPI AGCancers2072-66942019-09-01119130210.3390/cancers11091302cancers11091302Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary TumorigenesisDaniela D’Angelo0Marco De Martino1Claudio Arra2Alfredo Fusco3Istituto di Endocrinologia ed Oncologia Sperimentale—Consiglio Nazionale delle Ricerche (CNR) c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyIstituto di Endocrinologia ed Oncologia Sperimentale—Consiglio Nazionale delle Ricerche (CNR) c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyStruttura Semplice Dipartimentale Sperimentazione Animale, Istituto Nazionale dei Tumori, Fondazione Pascale, 80131 Naples, ItalyIstituto di Endocrinologia ed Oncologia Sperimentale—Consiglio Nazionale delle Ricerche (CNR) c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyTwo novel molecular mechanisms with a driver role in pituitary tumorigenesis have been recently identified. They are (a) mutations in the Ubiquitin-Specific Protease 8 (USP8) gene in corticotroph tumors and (b) overexpression of the <i>HMGA1</i> and <i>HMGA2</i> genes in most of the pituitary tumors. Moreover, deregulated expression of the non-coding RNAs has been very frequently observed in this neoplasia. The aim of this review is to better elucidate the role, the mechanisms, and the possible clinical impact of these novel alterations in the development of pituitary neoplasia.https://www.mdpi.com/2072-6694/11/9/1302pituitary tumorsepigeneticsHMGAUSP8non-coding RNAs |
| spellingShingle | Daniela D’Angelo Marco De Martino Claudio Arra Alfredo Fusco Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis Cancers pituitary tumors epigenetics HMGA USP8 non-coding RNAs |
| title | Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis |
| title_full | Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis |
| title_fullStr | Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis |
| title_full_unstemmed | Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis |
| title_short | Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis |
| title_sort | emerging role of usp8 hmga and non coding rnas in pituitary tumorigenesis |
| topic | pituitary tumors epigenetics HMGA USP8 non-coding RNAs |
| url | https://www.mdpi.com/2072-6694/11/9/1302 |
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