lncRNA polymorphism affects the prognosis of gastric cancer
Abstract Background Previous studies have found that lncRNA polymorphisms are associated with the prognosis of gastric cancer (GC), but the specific roles of many lncRNA polymorphism sites in gastric cancer are still unclear. Our study aims to deeply explore the relationship between genetic polymorp...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02723-x |
| _version_ | 1817986886190235648 |
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| author | Yanping Lyu Shuangfeng Yang Xuejie Lyu Yuan-Liang Wang Shumi Ji Shuling Kang Yu Jiang Jianjun Xiang Chenzhou He Peixin Li Baoying Liu Chuancheng Wu |
| author_facet | Yanping Lyu Shuangfeng Yang Xuejie Lyu Yuan-Liang Wang Shumi Ji Shuling Kang Yu Jiang Jianjun Xiang Chenzhou He Peixin Li Baoying Liu Chuancheng Wu |
| author_sort | Yanping Lyu |
| collection | DOAJ |
| description | Abstract Background Previous studies have found that lncRNA polymorphisms are associated with the prognosis of gastric cancer (GC), but the specific roles of many lncRNA polymorphism sites in gastric cancer are still unclear. Our study aims to deeply explore the relationship between genetic polymorphism of lncRNA and the prognosis of GC. Methods The genotypes of candidate SNP locus were detected by Sequenom Mass ARRAY SNP. We deeply analyzed the association of lncRNA polymorphisms with GC prognosis by univariate and multivariate Cox regression, stratified analysis, conjoint analysis, and log-rank test. Results We found that mutations at rs2579878 and rs10036719 loci reduced the risk of poor prognosis of GC. Stratified analysis showed that rs2795025, rs10036719, and rs12516079 polymorphisms were all associated with tumor prognosis. In addition, conjoint analyses showed that the interaction between these two polymorphic sites (rs2795025 and rs12516079) could increase the risk of poor prognosis. Multivariate analysis also found that the AG/AA genotype of rs10036719 and AG genotype of rs12516079 were independent prognostic factors. Moreover, the high expression of both CCDC26 and LINC02122 were shown to be associated with the poor survival status of GC patients. Conclusions We find that the genetic polymorphism of lncRNA plays a role in the development of GC and is closely related to the survival time of patients. It could serve as a predictor of the prognosis of GC. |
| first_indexed | 2024-04-14T00:14:59Z |
| format | Article |
| id | doaj.art-4de13c961b2848a289788208cb07c2a6 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-14T00:14:59Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-4de13c961b2848a289788208cb07c2a62022-12-22T02:23:09ZengBMCWorld Journal of Surgical Oncology1477-78192022-08-0120111410.1186/s12957-022-02723-xlncRNA polymorphism affects the prognosis of gastric cancerYanping Lyu0Shuangfeng Yang1Xuejie Lyu2Yuan-Liang Wang3Shumi Ji4Shuling Kang5Yu Jiang6Jianjun Xiang7Chenzhou He8Peixin Li9Baoying Liu10Chuancheng Wu11Department of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityDepartment of Preventive Medicine, School of Public Health, Fujian Medical UniversityAbstract Background Previous studies have found that lncRNA polymorphisms are associated with the prognosis of gastric cancer (GC), but the specific roles of many lncRNA polymorphism sites in gastric cancer are still unclear. Our study aims to deeply explore the relationship between genetic polymorphism of lncRNA and the prognosis of GC. Methods The genotypes of candidate SNP locus were detected by Sequenom Mass ARRAY SNP. We deeply analyzed the association of lncRNA polymorphisms with GC prognosis by univariate and multivariate Cox regression, stratified analysis, conjoint analysis, and log-rank test. Results We found that mutations at rs2579878 and rs10036719 loci reduced the risk of poor prognosis of GC. Stratified analysis showed that rs2795025, rs10036719, and rs12516079 polymorphisms were all associated with tumor prognosis. In addition, conjoint analyses showed that the interaction between these two polymorphic sites (rs2795025 and rs12516079) could increase the risk of poor prognosis. Multivariate analysis also found that the AG/AA genotype of rs10036719 and AG genotype of rs12516079 were independent prognostic factors. Moreover, the high expression of both CCDC26 and LINC02122 were shown to be associated with the poor survival status of GC patients. Conclusions We find that the genetic polymorphism of lncRNA plays a role in the development of GC and is closely related to the survival time of patients. It could serve as a predictor of the prognosis of GC.https://doi.org/10.1186/s12957-022-02723-xGClncRNAGenePolymorphismPrognosis |
| spellingShingle | Yanping Lyu Shuangfeng Yang Xuejie Lyu Yuan-Liang Wang Shumi Ji Shuling Kang Yu Jiang Jianjun Xiang Chenzhou He Peixin Li Baoying Liu Chuancheng Wu lncRNA polymorphism affects the prognosis of gastric cancer World Journal of Surgical Oncology GC lncRNA Gene Polymorphism Prognosis |
| title | lncRNA polymorphism affects the prognosis of gastric cancer |
| title_full | lncRNA polymorphism affects the prognosis of gastric cancer |
| title_fullStr | lncRNA polymorphism affects the prognosis of gastric cancer |
| title_full_unstemmed | lncRNA polymorphism affects the prognosis of gastric cancer |
| title_short | lncRNA polymorphism affects the prognosis of gastric cancer |
| title_sort | lncrna polymorphism affects the prognosis of gastric cancer |
| topic | GC lncRNA Gene Polymorphism Prognosis |
| url | https://doi.org/10.1186/s12957-022-02723-x |
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