The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory?
Non-clear cell renal cell carcinomas are a miscellaneous group of tumors that include different histological subtypes, each one characterized by peculiarity in terms of genetic alteration, clinical behavior, prognosis, and treatment response. Because of their low incidence and poor enrollment in cli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6237 |
| _version_ | 1797530725925257216 |
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| author | Andrea Marchetti Matteo Rosellini Veronica Mollica Alessandro Rizzo Elisa Tassinari Giacomo Nuvola Alessia Cimadamore Matteo Santoni Michelangelo Fiorentino Rodolfo Montironi Francesco Massari |
| author_facet | Andrea Marchetti Matteo Rosellini Veronica Mollica Alessandro Rizzo Elisa Tassinari Giacomo Nuvola Alessia Cimadamore Matteo Santoni Michelangelo Fiorentino Rodolfo Montironi Francesco Massari |
| author_sort | Andrea Marchetti |
| collection | DOAJ |
| description | Non-clear cell renal cell carcinomas are a miscellaneous group of tumors that include different histological subtypes, each one characterized by peculiarity in terms of genetic alteration, clinical behavior, prognosis, and treatment response. Because of their low incidence and poor enrollment in clinical trials, alongside their heterogeneity, additional efforts are required to better unveil the pathogenetic mechanisms and, consequently, to improve the treatment algorithm. Nowadays, tyrosine kinase inhibitors, mTOR and MET inhibitors, and even cisplatin-based chemotherapy and immunotherapy are potential weapons that are still under evaluation in this setting. Various biomarkers have been evaluated for detecting progression and monitoring renal cell carcinoma, but more studies are necessary to improve this field. In this review, we provide an overview on the molecular characteristics of this group of tumors and the recently published trials, giving an insight into what might become the future therapeutic standard in this complex world of non-clear cell kidney cancers. |
| first_indexed | 2024-03-10T10:33:07Z |
| format | Article |
| id | doaj.art-4de2183bf7a7446088d79b6a945ef71a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:33:07Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4de2183bf7a7446088d79b6a945ef71a2023-11-21T23:27:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212623710.3390/ijms22126237The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory?Andrea Marchetti0Matteo Rosellini1Veronica Mollica2Alessandro Rizzo3Elisa Tassinari4Giacomo Nuvola5Alessia Cimadamore6Matteo Santoni7Michelangelo Fiorentino8Rodolfo Montironi9Francesco Massari10Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni—15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni—15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni—15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni—15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni—15, 40138 Bologna, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni—15, 40138 Bologna, ItalySection of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, 60126 Ancona, ItalyOncology Unit, Macerata Hospital, 62100 Macerata, ItalyDepartment of Specialistic Diagnostic and Experimental Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalySection of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, 60126 Ancona, ItalyMedical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni—15, 40138 Bologna, ItalyNon-clear cell renal cell carcinomas are a miscellaneous group of tumors that include different histological subtypes, each one characterized by peculiarity in terms of genetic alteration, clinical behavior, prognosis, and treatment response. Because of their low incidence and poor enrollment in clinical trials, alongside their heterogeneity, additional efforts are required to better unveil the pathogenetic mechanisms and, consequently, to improve the treatment algorithm. Nowadays, tyrosine kinase inhibitors, mTOR and MET inhibitors, and even cisplatin-based chemotherapy and immunotherapy are potential weapons that are still under evaluation in this setting. Various biomarkers have been evaluated for detecting progression and monitoring renal cell carcinoma, but more studies are necessary to improve this field. In this review, we provide an overview on the molecular characteristics of this group of tumors and the recently published trials, giving an insight into what might become the future therapeutic standard in this complex world of non-clear cell kidney cancers.https://www.mdpi.com/1422-0067/22/12/6237non-clear cell renal cell carcinomapapillary RCCchromophobe RCCTKIimmunotherapymolecular targets |
| spellingShingle | Andrea Marchetti Matteo Rosellini Veronica Mollica Alessandro Rizzo Elisa Tassinari Giacomo Nuvola Alessia Cimadamore Matteo Santoni Michelangelo Fiorentino Rodolfo Montironi Francesco Massari The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory? International Journal of Molecular Sciences non-clear cell renal cell carcinoma papillary RCC chromophobe RCC TKI immunotherapy molecular targets |
| title | The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory? |
| title_full | The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory? |
| title_fullStr | The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory? |
| title_full_unstemmed | The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory? |
| title_short | The Molecular Characteristics of Non-Clear Cell Renal Cell Carcinoma: What’s the Story Morning Glory? |
| title_sort | molecular characteristics of non clear cell renal cell carcinoma what s the story morning glory |
| topic | non-clear cell renal cell carcinoma papillary RCC chromophobe RCC TKI immunotherapy molecular targets |
| url | https://www.mdpi.com/1422-0067/22/12/6237 |
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