Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage
ObjectiveTo investigate the association between cerebral small vessel disease (SVD) and hematoma volume in primary intracerebral hemorrhage (ICH).MethodsPatients from a prospective ICH cohort were enrolled. Admission and follow-up CT scan within 72 h after onset were reviewed to calculate the final...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.888198/full |
| _version_ | 1818211073805778944 |
|---|---|
| author | Zi-Jie Wang Rui Zhao Xiao Hu Wen-Song Yang Wen-Song Yang Lan Deng Xin-Ni Lv Zuo-Qiao Li Jing Cheng Ming-Jun Pu Zhou-Ping Tang Guo-Feng Wu Li-Bo Zhao Peng Xie Peng Xie Qi Li Qi Li Qi Li |
| author_facet | Zi-Jie Wang Rui Zhao Xiao Hu Wen-Song Yang Wen-Song Yang Lan Deng Xin-Ni Lv Zuo-Qiao Li Jing Cheng Ming-Jun Pu Zhou-Ping Tang Guo-Feng Wu Li-Bo Zhao Peng Xie Peng Xie Qi Li Qi Li Qi Li |
| author_sort | Zi-Jie Wang |
| collection | DOAJ |
| description | ObjectiveTo investigate the association between cerebral small vessel disease (SVD) and hematoma volume in primary intracerebral hemorrhage (ICH).MethodsPatients from a prospective ICH cohort were enrolled. Admission and follow-up CT scan within 72 h after onset were reviewed to calculate the final hematoma volume. We evaluated cortical superficial siderosis and the global SVD score, including white matter hyperintensities, lacunes, enlarged perivascular space, and cerebral microbleeds on MRI. We conducted the multivariate logistic regression analyses to explore the association between SVD markers and small ICH, as well as hematoma volume. Hematoma location was stratified into lobar and non-lobar for subgroup analysis.ResultsA total of 187 patients with primary ICH (mean age 62.4 ± 13.4 years, 67.9% male) were enrolled. 94 (50.2%) patients had small ICH. The multivariate logistic regression analysis showed an association between global SVD score and small ICH [adjusted odds ratio (aOR) 1.27, 95% CI 1.03–1.57, p = 0.027] and a trend of higher global SVD score towards non-lobar small ICH (aOR 1.23, 95% CI 0.95–1.58, p = 0.122). In the multivariate linear regression analysis, global SVD score was inversely related to hematoma volume of all ICH (β = −0.084, 95% CI −0.142 to −0.025, p = 0.005) and non-lobar ICH (β = −0.112, 95% CI −0.186 to −0.037, p = 0.004). Lacune (β = −0.245, 95% CI −0.487 to −0.004, p = 0.046) was associated with lower non-lobar ICH volume.ConclusionGlobal SVD score is associated with small ICH and inversely correlated with hematoma volume. This finding predominantly exists in non-lobar ICH. |
| first_indexed | 2024-12-12T05:26:42Z |
| format | Article |
| id | doaj.art-4de2e1f3bab942eab5a350b3db742afe |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T05:26:42Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-4de2e1f3bab942eab5a350b3db742afe2022-12-22T00:36:27ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-05-011610.3389/fnins.2022.888198888198Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral HemorrhageZi-Jie Wang0Rui Zhao1Xiao Hu2Wen-Song Yang3Wen-Song Yang4Lan Deng5Xin-Ni Lv6Zuo-Qiao Li7Jing Cheng8Ming-Jun Pu9Zhou-Ping Tang10Guo-Feng Wu11Li-Bo Zhao12Peng Xie13Peng Xie14Qi Li15Qi Li16Qi Li17Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaEmergency Department, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United StatesObjectiveTo investigate the association between cerebral small vessel disease (SVD) and hematoma volume in primary intracerebral hemorrhage (ICH).MethodsPatients from a prospective ICH cohort were enrolled. Admission and follow-up CT scan within 72 h after onset were reviewed to calculate the final hematoma volume. We evaluated cortical superficial siderosis and the global SVD score, including white matter hyperintensities, lacunes, enlarged perivascular space, and cerebral microbleeds on MRI. We conducted the multivariate logistic regression analyses to explore the association between SVD markers and small ICH, as well as hematoma volume. Hematoma location was stratified into lobar and non-lobar for subgroup analysis.ResultsA total of 187 patients with primary ICH (mean age 62.4 ± 13.4 years, 67.9% male) were enrolled. 94 (50.2%) patients had small ICH. The multivariate logistic regression analysis showed an association between global SVD score and small ICH [adjusted odds ratio (aOR) 1.27, 95% CI 1.03–1.57, p = 0.027] and a trend of higher global SVD score towards non-lobar small ICH (aOR 1.23, 95% CI 0.95–1.58, p = 0.122). In the multivariate linear regression analysis, global SVD score was inversely related to hematoma volume of all ICH (β = −0.084, 95% CI −0.142 to −0.025, p = 0.005) and non-lobar ICH (β = −0.112, 95% CI −0.186 to −0.037, p = 0.004). Lacune (β = −0.245, 95% CI −0.487 to −0.004, p = 0.046) was associated with lower non-lobar ICH volume.ConclusionGlobal SVD score is associated with small ICH and inversely correlated with hematoma volume. This finding predominantly exists in non-lobar ICH.https://www.frontiersin.org/articles/10.3389/fnins.2022.888198/fullintracerebral hemorrhagecerebral small vessel diseasecomputed tomographymagnetic resonance imagingneuroimagingstroke |
| spellingShingle | Zi-Jie Wang Rui Zhao Xiao Hu Wen-Song Yang Wen-Song Yang Lan Deng Xin-Ni Lv Zuo-Qiao Li Jing Cheng Ming-Jun Pu Zhou-Ping Tang Guo-Feng Wu Li-Bo Zhao Peng Xie Peng Xie Qi Li Qi Li Qi Li Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage Frontiers in Neuroscience intracerebral hemorrhage cerebral small vessel disease computed tomography magnetic resonance imaging neuroimaging stroke |
| title | Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage |
| title_full | Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage |
| title_fullStr | Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage |
| title_full_unstemmed | Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage |
| title_short | Higher Cerebral Small Vessel Disease Burden in Patients With Small Intracerebral Hemorrhage |
| title_sort | higher cerebral small vessel disease burden in patients with small intracerebral hemorrhage |
| topic | intracerebral hemorrhage cerebral small vessel disease computed tomography magnetic resonance imaging neuroimaging stroke |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.888198/full |
| work_keys_str_mv | AT zijiewang highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT ruizhao highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT xiaohu highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT wensongyang highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT wensongyang highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT landeng highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT xinnilv highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT zuoqiaoli highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT jingcheng highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT mingjunpu highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT zhoupingtang highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT guofengwu highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT libozhao highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT pengxie highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT pengxie highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT qili highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT qili highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage AT qili highercerebralsmallvesseldiseaseburdeninpatientswithsmallintracerebralhemorrhage |