Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics
Conventional anticancer treatments, such as radiotherapy and chemotherapy, have significantly improved cancer therapy. Nevertheless, the existing traditional anticancer treatments have been reported to cause serious side effects and resistance to cancer and even to severely affect the quality of lif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/24/8659 |
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| author | Ali A. Rabaan Rehab Bukhamsin Hajir AlSaihati Saleh A. Alshamrani Jehad AlSihati Hani M. Al-Afghani Roua A. Alsubki Abdulmonem A. Abuzaid Saleh Al-Abdulhadi Yahya Aldawood Abdulmonem A. Alsaleh Yousef N. Alhashem Jenan A. Almatouq Talha Bin Emran Shamsah H. Al-Ahmed Firzan Nainu Ranjan K. Mohapatra |
| author_facet | Ali A. Rabaan Rehab Bukhamsin Hajir AlSaihati Saleh A. Alshamrani Jehad AlSihati Hani M. Al-Afghani Roua A. Alsubki Abdulmonem A. Abuzaid Saleh Al-Abdulhadi Yahya Aldawood Abdulmonem A. Alsaleh Yousef N. Alhashem Jenan A. Almatouq Talha Bin Emran Shamsah H. Al-Ahmed Firzan Nainu Ranjan K. Mohapatra |
| author_sort | Ali A. Rabaan |
| collection | DOAJ |
| description | Conventional anticancer treatments, such as radiotherapy and chemotherapy, have significantly improved cancer therapy. Nevertheless, the existing traditional anticancer treatments have been reported to cause serious side effects and resistance to cancer and even to severely affect the quality of life of cancer survivors, which indicates the utmost urgency to develop effective and safe anticancer treatments. As the primary focus of cancer nanotheranostics, nanomaterials with unique surface chemistry and shape have been investigated for integrating cancer diagnostics with treatment techniques, including guiding a prompt diagnosis, precise imaging, treatment with an effective dose, and real-time supervision of therapeutic efficacy. Several theranostic nanosystems have been explored for cancer diagnosis and treatment in the past decade. However, metal-based nanotheranostics continue to be the most common types of nonentities. Consequently, the present review covers the physical characteristics of effective metallic, functionalized, and hybrid nanotheranostic systems. The scope of coverage also includes the clinical advantages and limitations of cancer nanotheranostics. In light of these viewpoints, future research directions exploring the robustness and clinical viability of cancer nanotheranostics through various strategies to enhance the biocompatibility of theranostic nanoparticles are summarised. |
| first_indexed | 2024-03-09T16:03:07Z |
| format | Article |
| id | doaj.art-4de382803c344ee58fa296db1931b5ef |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:03:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4de382803c344ee58fa296db1931b5ef2023-11-24T16:55:14ZengMDPI AGMolecules1420-30492022-12-012724865910.3390/molecules27248659Recent Trends and Developments in Multifunctional Nanoparticles for Cancer TheranosticsAli A. Rabaan0Rehab Bukhamsin1Hajir AlSaihati2Saleh A. Alshamrani3Jehad AlSihati4Hani M. Al-Afghani5Roua A. Alsubki6Abdulmonem A. Abuzaid7Saleh Al-Abdulhadi8Yahya Aldawood9Abdulmonem A. Alsaleh10Yousef N. Alhashem11Jenan A. Almatouq12Talha Bin Emran13Shamsah H. Al-Ahmed14Firzan Nainu15Ranjan K. Mohapatra16Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi ArabiaDammam Regional Laboratory and Blood Bank, Dammam 31411, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39831, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran 61441, Saudi ArabiaInternal Medicine Department, Gastroenterology Section, King Fahad Specialist Hospital, Dammam 31311, Saudi ArabiaLaboratory Department, Security Forces Hospital, Makkah 24269, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi ArabiaMedical Microbiology Department, Security Forces Hospital Programme, Dammam 32314, Saudi ArabiaDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Riyadh 11942, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Mohammed AlMana College of Health Sciences, Dammam 34222, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Mohammed AlMana College of Health Sciences, Dammam 34222, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Mohammed AlMana College of Health Sciences, Dammam 34222, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Mohammed AlMana College of Health Sciences, Dammam 34222, Saudi ArabiaDepartment of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, BangladeshSpecialty Paediatric Medicine, Qatif Central Hospital, Qatif 32654, Saudi ArabiaDepartment of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, IndonesiaDepartment of Chemistry, Government College of Engineering, Keonjhar 758002, IndiaConventional anticancer treatments, such as radiotherapy and chemotherapy, have significantly improved cancer therapy. Nevertheless, the existing traditional anticancer treatments have been reported to cause serious side effects and resistance to cancer and even to severely affect the quality of life of cancer survivors, which indicates the utmost urgency to develop effective and safe anticancer treatments. As the primary focus of cancer nanotheranostics, nanomaterials with unique surface chemistry and shape have been investigated for integrating cancer diagnostics with treatment techniques, including guiding a prompt diagnosis, precise imaging, treatment with an effective dose, and real-time supervision of therapeutic efficacy. Several theranostic nanosystems have been explored for cancer diagnosis and treatment in the past decade. However, metal-based nanotheranostics continue to be the most common types of nonentities. Consequently, the present review covers the physical characteristics of effective metallic, functionalized, and hybrid nanotheranostic systems. The scope of coverage also includes the clinical advantages and limitations of cancer nanotheranostics. In light of these viewpoints, future research directions exploring the robustness and clinical viability of cancer nanotheranostics through various strategies to enhance the biocompatibility of theranostic nanoparticles are summarised.https://www.mdpi.com/1420-3049/27/24/8659cancer therapynanotheranosticsplasmonic nanoparticlesdrug deliverynanomaterials |
| spellingShingle | Ali A. Rabaan Rehab Bukhamsin Hajir AlSaihati Saleh A. Alshamrani Jehad AlSihati Hani M. Al-Afghani Roua A. Alsubki Abdulmonem A. Abuzaid Saleh Al-Abdulhadi Yahya Aldawood Abdulmonem A. Alsaleh Yousef N. Alhashem Jenan A. Almatouq Talha Bin Emran Shamsah H. Al-Ahmed Firzan Nainu Ranjan K. Mohapatra Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics Molecules cancer therapy nanotheranostics plasmonic nanoparticles drug delivery nanomaterials |
| title | Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics |
| title_full | Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics |
| title_fullStr | Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics |
| title_full_unstemmed | Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics |
| title_short | Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics |
| title_sort | recent trends and developments in multifunctional nanoparticles for cancer theranostics |
| topic | cancer therapy nanotheranostics plasmonic nanoparticles drug delivery nanomaterials |
| url | https://www.mdpi.com/1420-3049/27/24/8659 |
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