Salivary Interleukin-6 - A pioneering marker for correlating diabetes and chronic periodontitis: A comparative study
Background: Periodontitis is a chronic inflammatory disease which is multifactorial. Diabetes mellitus (DM) is one of the major systemic factors to influence the severity of chronic periodontitis. Numerous inflammatory markers are produced in the course of the disease which is secreted in saliva too...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Journal of Dental Research |
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| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2017;volume=28;issue=2;spage=133;epage=137;aulast=Balaji |
| _version_ | 1828379428352163840 |
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| author | Anitha Balaji S C Chandrasekaran D Subramanium A B Fernz |
| author_facet | Anitha Balaji S C Chandrasekaran D Subramanium A B Fernz |
| author_sort | Anitha Balaji |
| collection | DOAJ |
| description | Background: Periodontitis is a chronic inflammatory disease which is multifactorial. Diabetes mellitus (DM) is one of the major systemic factors to influence the severity of chronic periodontitis. Numerous inflammatory markers are produced in the course of the disease which is secreted in saliva too. This study evaluates the salivary concentrations of interleukin-6 (IL-6) in periodontitis patients with type 2 diabetes. Materials and Methods: Whole saliva samples were collected from eighty patients who were further divided into four groups; healthy (control group; n = 20), untreated periodontitis (UPD; n = 20), DM (DM; n = 20), and UPD + DM (n = 20 groups). Salivary IL-6 concentrations were determined by standard enzyme-linked immunosorbent assay. Results: Results show that the UPD patients with and without DM exhibited higher concentrations of salivary IL-6 than the control group and diabetes groups. Further, the salivary IL-6 was correlated with glycosylated hemoglobin A levels in patients with diabetes. Conclusion: Concentration of salivary IL-6 was elevated in patients with periodontitis with and without diabetes. Thus, salivary IL–6 levels can be considered as an important biomarker in the diagnosis of periodontitis and diabetes. |
| first_indexed | 2024-12-10T03:40:44Z |
| format | Article |
| id | doaj.art-4de428f49f4f4d518ba40ba1bf9fe251 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-12-10T03:40:44Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-4de428f49f4f4d518ba40ba1bf9fe2512022-12-22T02:03:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032017-01-0128213313710.4103/ijdr.IJDR_167_14Salivary Interleukin-6 - A pioneering marker for correlating diabetes and chronic periodontitis: A comparative studyAnitha BalajiS C ChandrasekaranD SubramaniumA B FernzBackground: Periodontitis is a chronic inflammatory disease which is multifactorial. Diabetes mellitus (DM) is one of the major systemic factors to influence the severity of chronic periodontitis. Numerous inflammatory markers are produced in the course of the disease which is secreted in saliva too. This study evaluates the salivary concentrations of interleukin-6 (IL-6) in periodontitis patients with type 2 diabetes. Materials and Methods: Whole saliva samples were collected from eighty patients who were further divided into four groups; healthy (control group; n = 20), untreated periodontitis (UPD; n = 20), DM (DM; n = 20), and UPD + DM (n = 20 groups). Salivary IL-6 concentrations were determined by standard enzyme-linked immunosorbent assay. Results: Results show that the UPD patients with and without DM exhibited higher concentrations of salivary IL-6 than the control group and diabetes groups. Further, the salivary IL-6 was correlated with glycosylated hemoglobin A levels in patients with diabetes. Conclusion: Concentration of salivary IL-6 was elevated in patients with periodontitis with and without diabetes. Thus, salivary IL–6 levels can be considered as an important biomarker in the diagnosis of periodontitis and diabetes.http://www.ijdr.in/article.asp?issn=0970-9290;year=2017;volume=28;issue=2;spage=133;epage=137;aulast=BalajiDiabetes mellitusglycosylated hemoglobin Ainterleukin-6periodontitissaliva |
| spellingShingle | Anitha Balaji S C Chandrasekaran D Subramanium A B Fernz Salivary Interleukin-6 - A pioneering marker for correlating diabetes and chronic periodontitis: A comparative study Indian Journal of Dental Research Diabetes mellitus glycosylated hemoglobin A interleukin-6 periodontitis saliva |
| title | Salivary Interleukin-6 - A pioneering marker for correlating diabetes and chronic periodontitis: A comparative study |
| title_full | Salivary Interleukin-6 - A pioneering marker for correlating diabetes and chronic periodontitis: A comparative study |
| title_fullStr | Salivary Interleukin-6 - A pioneering marker for correlating diabetes and chronic periodontitis: A comparative study |
| title_full_unstemmed | Salivary Interleukin-6 - A pioneering marker for correlating diabetes and chronic periodontitis: A comparative study |
| title_short | Salivary Interleukin-6 - A pioneering marker for correlating diabetes and chronic periodontitis: A comparative study |
| title_sort | salivary interleukin 6 a pioneering marker for correlating diabetes and chronic periodontitis a comparative study |
| topic | Diabetes mellitus glycosylated hemoglobin A interleukin-6 periodontitis saliva |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2017;volume=28;issue=2;spage=133;epage=137;aulast=Balaji |
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