Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue
Epimorphic regeneration in New Zealand rabbit ear is an interesting example of mammalian wound healing in which blastema formation is involved in replacement of injured tissues. It has been suggested that isolated cells from regenerating rabbit ear possess stem-like properties. In this study, we aim...
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| Format: | Article |
| Language: | English |
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Universitat Politècnica de València
2016-06-01
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| Series: | World Rabbit Science |
| Subjects: | |
| Online Access: | http://polipapers.upv.es/index.php/wrs/article/view/3965 |
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| author | A. S. Javanmard A. R. Bahrami Z. Mahmoudi M. Saeinasab N. Mahdavi-Shahri M. Moghaddam Matin |
| author_facet | A. S. Javanmard A. R. Bahrami Z. Mahmoudi M. Saeinasab N. Mahdavi-Shahri M. Moghaddam Matin |
| author_sort | A. S. Javanmard |
| collection | DOAJ |
| description | Epimorphic regeneration in New Zealand rabbit ear is an interesting example of mammalian wound healing in which blastema formation is involved in replacement of injured tissues. It has been suggested that isolated cells from regenerating rabbit ear possess stem-like properties. In this study, we aimed to determine the expression of stemness markers, OCT4 and SOX2 proteins, in regenerating rabbit tissues by immunohistochemistry. Results indicated that both proteins could be detected in epithelial cells, hair follicle cells and perichondrium cells. Expression pattern analysis of OCT4 and SOX2 proteins showed no clear differences between regenerative and non-regenerative control tissues. According to several reports of OCT4 and SOX2 proteins expression in adult stem cells, it could be proposed that OCT4 and SOX2 expressing cells in regenerating rabbit ear tissues are progenitor/adult stem cells which are resident in these tissues, and other markers should be used for detection of blastema cells. |
| first_indexed | 2024-12-13T12:36:24Z |
| format | Article |
| id | doaj.art-4de46e695da84fc3b0bb26bfe3897bf5 |
| institution | Directory Open Access Journal |
| issn | 1257-5011 1989-8886 |
| language | English |
| last_indexed | 2024-12-13T12:36:24Z |
| publishDate | 2016-06-01 |
| publisher | Universitat Politècnica de València |
| record_format | Article |
| series | World Rabbit Science |
| spelling | doaj.art-4de46e695da84fc3b0bb26bfe3897bf52022-12-21T23:45:51ZengUniversitat Politècnica de ValènciaWorld Rabbit Science1257-50111989-88862016-06-0124215516410.4995/wrs.2016.39654419Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissueA. S. Javanmard0A. R. Bahrami1Z. Mahmoudi2M. Saeinasab3N. Mahdavi-Shahri4M. Moghaddam Matin5Ferdowsi University of MashhadFerdowsi University of MashhadFerdowsi University of MashhadFerdowsi University of MashhadFerdowsi University of MashhadFerdowsi University of MashhadEpimorphic regeneration in New Zealand rabbit ear is an interesting example of mammalian wound healing in which blastema formation is involved in replacement of injured tissues. It has been suggested that isolated cells from regenerating rabbit ear possess stem-like properties. In this study, we aimed to determine the expression of stemness markers, OCT4 and SOX2 proteins, in regenerating rabbit tissues by immunohistochemistry. Results indicated that both proteins could be detected in epithelial cells, hair follicle cells and perichondrium cells. Expression pattern analysis of OCT4 and SOX2 proteins showed no clear differences between regenerative and non-regenerative control tissues. According to several reports of OCT4 and SOX2 proteins expression in adult stem cells, it could be proposed that OCT4 and SOX2 expressing cells in regenerating rabbit ear tissues are progenitor/adult stem cells which are resident in these tissues, and other markers should be used for detection of blastema cells.http://polipapers.upv.es/index.php/wrs/article/view/3965regenerating rabbit earOCT4SOX2adult stem cells |
| spellingShingle | A. S. Javanmard A. R. Bahrami Z. Mahmoudi M. Saeinasab N. Mahdavi-Shahri M. Moghaddam Matin Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue World Rabbit Science regenerating rabbit ear OCT4 SOX2 adult stem cells |
| title | Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue |
| title_full | Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue |
| title_fullStr | Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue |
| title_full_unstemmed | Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue |
| title_short | Studying the expression patterns of OCT4 and SOX2 proteins in regenerating rabbit ear tissue |
| title_sort | studying the expression patterns of oct4 and sox2 proteins in regenerating rabbit ear tissue |
| topic | regenerating rabbit ear OCT4 SOX2 adult stem cells |
| url | http://polipapers.upv.es/index.php/wrs/article/view/3965 |
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