Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole Mitochondria
Kidney function highly depends on mitochondria, organelles that regulate different metabolic pathways. Mitochondria-altered function and structure are present during acute kidney injury (AKI) and chronic kidney disease (CKD). Targeting mitochondria using several strategies has been shown to improve...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Future Pharmacology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-9879/2/3/17 |
| _version_ | 1797465227725373440 |
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| author | Alexis Paulina Jiménez-Uribe José Pedraza-Chaverri |
| author_facet | Alexis Paulina Jiménez-Uribe José Pedraza-Chaverri |
| author_sort | Alexis Paulina Jiménez-Uribe |
| collection | DOAJ |
| description | Kidney function highly depends on mitochondria, organelles that regulate different metabolic pathways. Mitochondria-altered function and structure are present during acute kidney injury (AKI) and chronic kidney disease (CKD). Targeting mitochondria using several strategies has been shown to improve kidney function. Here, we review some experimental mitochondria targeting strategies with clinical potential in kidney diseases encompassing cationic/lipophilic small molecules, peptides, nanocarriers, and even the entire organelle. |
| first_indexed | 2024-03-09T18:19:31Z |
| format | Article |
| id | doaj.art-4de5b878cc7b4ffd9b394d2d5ab5f8ba |
| institution | Directory Open Access Journal |
| issn | 2673-9879 |
| language | English |
| last_indexed | 2024-03-09T18:19:31Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj.art-4de5b878cc7b4ffd9b394d2d5ab5f8ba2023-11-24T08:25:38ZengMDPI AGFuture Pharmacology2673-98792022-07-012325627510.3390/futurepharmacol2030017Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole MitochondriaAlexis Paulina Jiménez-Uribe0José Pedraza-Chaverri1Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoDepartamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoKidney function highly depends on mitochondria, organelles that regulate different metabolic pathways. Mitochondria-altered function and structure are present during acute kidney injury (AKI) and chronic kidney disease (CKD). Targeting mitochondria using several strategies has been shown to improve kidney function. Here, we review some experimental mitochondria targeting strategies with clinical potential in kidney diseases encompassing cationic/lipophilic small molecules, peptides, nanocarriers, and even the entire organelle.https://www.mdpi.com/2673-9879/2/3/17mitochondrial alterationskidney diseasesmitochondria targeting therapy |
| spellingShingle | Alexis Paulina Jiménez-Uribe José Pedraza-Chaverri Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole Mitochondria Future Pharmacology mitochondrial alterations kidney diseases mitochondria targeting therapy |
| title | Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole Mitochondria |
| title_full | Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole Mitochondria |
| title_fullStr | Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole Mitochondria |
| title_full_unstemmed | Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole Mitochondria |
| title_short | Promising Therapeutic Strategies Targeting Mitochondria in Kidney Diseases: From Small Molecules to Whole Mitochondria |
| title_sort | promising therapeutic strategies targeting mitochondria in kidney diseases from small molecules to whole mitochondria |
| topic | mitochondrial alterations kidney diseases mitochondria targeting therapy |
| url | https://www.mdpi.com/2673-9879/2/3/17 |
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