Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials
Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Gut dysbiosis is hypothesized to cause PD; therefore, whether probiotics can be used as adjuvants in the treatment of PD is being actively investigated. Aims We performed a systematic review a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Gut Pathogens |
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| Online Access: | https://doi.org/10.1186/s13099-023-00536-1 |
| _version_ | 1797864554477125632 |
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| author | Jong Mi Park Sang Chul Lee Chorom Ham Yong Wook Kim |
| author_facet | Jong Mi Park Sang Chul Lee Chorom Ham Yong Wook Kim |
| author_sort | Jong Mi Park |
| collection | DOAJ |
| description | Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Gut dysbiosis is hypothesized to cause PD; therefore, whether probiotics can be used as adjuvants in the treatment of PD is being actively investigated. Aims We performed a systematic review and meta-analysis to evaluate the effectiveness of probiotic therapy in PD patients. Methods PUBMED/MEDLINE, EMBASE, Cochrane, Scopus, PsycINFO and Web of Science databases were searched till February 20, 2023. The meta-analysis used a random effects model and the effect size was calculated as mean difference or standardized mean difference. We assessed the quality of the evidence using the Grade of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results Eleven studies involving 840 participants were included in the final analysis. This meta-analysis showed high-quality evidence of improvement in Unified PD Rating Scale Part III motor scale (standardized mean difference [95% confidence interval]) (− 0.65 [− 1.11 to − 0.19]), non-motor symptom (− 0.81 [− 1.12 to − 0.51]), and depression scale (− 0.70 [− 0.93 to -0.46]). Moderate to low quality evidence of significant improvement was observed in gastrointestinal motility (0.83 [0.45–1.10]), quality of life (− 1.02 [− 1.66 to − 0.37]), anxiety scale (− 0.72 [− 1.10 to − 0.35]), serum inflammatory markers (− 5.98 [− 9.20 to − 2.75]), and diabetes risk (− 3.46 [− 4.72 to − 2.20]). However, there were no significant improvements in Bristol Stool Scale scores, constipation, antioxidant capacity, and risk of dyslipidemia. In a subgroup analysis, probiotic capsules improved gastrointestinal motility compared to fermented milk. Conclusion Probiotic supplements may be suitable for improving the motor and non-motor symptoms of PD and reducing depression. Further research is warranted to determine the mechanism of action of probiotics and to determine the optimal treatment protocol. |
| first_indexed | 2024-04-09T22:54:51Z |
| format | Article |
| id | doaj.art-4de5f3bbe4e54b599f1b6b7a1a267022 |
| institution | Directory Open Access Journal |
| issn | 1757-4749 |
| language | English |
| last_indexed | 2024-04-09T22:54:51Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Gut Pathogens |
| spelling | doaj.art-4de5f3bbe4e54b599f1b6b7a1a2670222023-03-22T11:20:23ZengBMCGut Pathogens1757-47492023-03-0115111710.1186/s13099-023-00536-1Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trialsJong Mi Park0Sang Chul Lee1Chorom Ham2Yong Wook Kim3Department and Research Institute of Rehabilitation Medicine, Yonsei University College of MedicineDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of MedicineDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of MedicineDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of MedicineAbstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Gut dysbiosis is hypothesized to cause PD; therefore, whether probiotics can be used as adjuvants in the treatment of PD is being actively investigated. Aims We performed a systematic review and meta-analysis to evaluate the effectiveness of probiotic therapy in PD patients. Methods PUBMED/MEDLINE, EMBASE, Cochrane, Scopus, PsycINFO and Web of Science databases were searched till February 20, 2023. The meta-analysis used a random effects model and the effect size was calculated as mean difference or standardized mean difference. We assessed the quality of the evidence using the Grade of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results Eleven studies involving 840 participants were included in the final analysis. This meta-analysis showed high-quality evidence of improvement in Unified PD Rating Scale Part III motor scale (standardized mean difference [95% confidence interval]) (− 0.65 [− 1.11 to − 0.19]), non-motor symptom (− 0.81 [− 1.12 to − 0.51]), and depression scale (− 0.70 [− 0.93 to -0.46]). Moderate to low quality evidence of significant improvement was observed in gastrointestinal motility (0.83 [0.45–1.10]), quality of life (− 1.02 [− 1.66 to − 0.37]), anxiety scale (− 0.72 [− 1.10 to − 0.35]), serum inflammatory markers (− 5.98 [− 9.20 to − 2.75]), and diabetes risk (− 3.46 [− 4.72 to − 2.20]). However, there were no significant improvements in Bristol Stool Scale scores, constipation, antioxidant capacity, and risk of dyslipidemia. In a subgroup analysis, probiotic capsules improved gastrointestinal motility compared to fermented milk. Conclusion Probiotic supplements may be suitable for improving the motor and non-motor symptoms of PD and reducing depression. Further research is warranted to determine the mechanism of action of probiotics and to determine the optimal treatment protocol.https://doi.org/10.1186/s13099-023-00536-1Parkinson’s diseaseProbioticsGastrointestinal motilityInflammationMeta-analysis |
| spellingShingle | Jong Mi Park Sang Chul Lee Chorom Ham Yong Wook Kim Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials Gut Pathogens Parkinson’s disease Probiotics Gastrointestinal motility Inflammation Meta-analysis |
| title | Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials |
| title_full | Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials |
| title_fullStr | Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials |
| title_short | Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials |
| title_sort | effect of probiotic supplementation on gastrointestinal motility inflammation motor non motor symptoms and mental health in parkinson s disease a meta analysis of randomized controlled trials |
| topic | Parkinson’s disease Probiotics Gastrointestinal motility Inflammation Meta-analysis |
| url | https://doi.org/10.1186/s13099-023-00536-1 |
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