IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient Hypercalcemia
A 67-year-old man with elevated serum immunoglobulin G4 (IgG4) levels, systemic lymphadenopathy infiltrated by IgG4-positive plasma cells, and Coombs-positive autoimmune hemolytic anemia (AIHA) showed marked hypercalcemia. Although the intact parathyroid hormone (PTH) level was elevated, 99mTc-MIBI...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-01-01
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| Series: | Clinical Medicine Insights: Case Reports |
| Online Access: | https://doi.org/10.4137/CCRep.S25553 |
| _version_ | 1818286885623037952 |
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| author | Sho Hasegawa Sohtaro Mine Shotaro Hagiwara |
| author_facet | Sho Hasegawa Sohtaro Mine Shotaro Hagiwara |
| author_sort | Sho Hasegawa |
| collection | DOAJ |
| description | A 67-year-old man with elevated serum immunoglobulin G4 (IgG4) levels, systemic lymphadenopathy infiltrated by IgG4-positive plasma cells, and Coombs-positive autoimmune hemolytic anemia (AIHA) showed marked hypercalcemia. Although the intact parathyroid hormone (PTH) level was elevated, 99mTc-MIBI scintigraphy and thyroid ultrasonography revealed no evidence of primary hyperparathyroidism. Liver biopsy showed marked infiltration of IgG4-positive plasma cells, which confirmed the diagnosis of IgG4-related disease (IgG4-RD). Corticosteroid therapy was initiated, and subsequently, intact PTH and serum calcium levels gradually normalized. Transient hypercalcemia in a patient with AIHA may therefore be associated with IgG4-RD. |
| first_indexed | 2024-12-13T01:31:42Z |
| format | Article |
| id | doaj.art-4de6f325816940a49cac8bac66e0a257 |
| institution | Directory Open Access Journal |
| issn | 1179-5476 |
| language | English |
| last_indexed | 2024-12-13T01:31:42Z |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Case Reports |
| spelling | doaj.art-4de6f325816940a49cac8bac66e0a2572022-12-22T00:03:59ZengSAGE PublishingClinical Medicine Insights: Case Reports1179-54762015-01-01810.4137/CCRep.S25553IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient HypercalcemiaSho Hasegawa0Sohtaro Mine1Shotaro Hagiwara2Department of NephrologyDepartment of PathologyDepartment of Hematology, National Center for Global Health and Medicine, Tokyo, Japan.A 67-year-old man with elevated serum immunoglobulin G4 (IgG4) levels, systemic lymphadenopathy infiltrated by IgG4-positive plasma cells, and Coombs-positive autoimmune hemolytic anemia (AIHA) showed marked hypercalcemia. Although the intact parathyroid hormone (PTH) level was elevated, 99mTc-MIBI scintigraphy and thyroid ultrasonography revealed no evidence of primary hyperparathyroidism. Liver biopsy showed marked infiltration of IgG4-positive plasma cells, which confirmed the diagnosis of IgG4-related disease (IgG4-RD). Corticosteroid therapy was initiated, and subsequently, intact PTH and serum calcium levels gradually normalized. Transient hypercalcemia in a patient with AIHA may therefore be associated with IgG4-RD.https://doi.org/10.4137/CCRep.S25553 |
| spellingShingle | Sho Hasegawa Sohtaro Mine Shotaro Hagiwara IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient Hypercalcemia Clinical Medicine Insights: Case Reports |
| title | IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient Hypercalcemia |
| title_full | IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient Hypercalcemia |
| title_fullStr | IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient Hypercalcemia |
| title_full_unstemmed | IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient Hypercalcemia |
| title_short | IgG4-Related Disease Combined with Autoimmune Hemolytic Anemia and Steroid-Responsive Transient Hypercalcemia |
| title_sort | igg4 related disease combined with autoimmune hemolytic anemia and steroid responsive transient hypercalcemia |
| url | https://doi.org/10.4137/CCRep.S25553 |
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