Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)
The effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrP<sup>Sc</sup>-like structure affecting the survival of SH-SY5Y cells. Quinacrine and minocycline prevented hPrP90-231-indu...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2011-01-01
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| Series: | Journal of Biological Research |
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| Online Access: | http://www.pagepressjournals.org/index.php/jbr/article/view/4689 |
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| author | V. Villa A. Corsaro S. Thellung A. Simi M. Nizzari M. Tonelli V. Boido A. Aceto T. Florio |
| author_facet | V. Villa A. Corsaro S. Thellung A. Simi M. Nizzari M. Tonelli V. Boido A. Aceto T. Florio |
| author_sort | V. Villa |
| collection | DOAJ |
| description | The effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrP<sup>Sc</sup>-like structure affecting the survival of SH-SY5Y cells. Quinacrine and minocycline prevented hPrP90-231-induced toxicity interfering with different mechanisms: protective effects of quinacrine are mediated by the binding to the fragment that abolished hPrP90-231 structural changes and cell internalization, whereas, minocycline reverted MAP kinase neurotoxic signaling exerted by the prion fragment. |
| first_indexed | 2024-12-14T10:50:14Z |
| format | Article |
| id | doaj.art-4de89126e8bb4db48737ffbd6150bb99 |
| institution | Directory Open Access Journal |
| issn | 1826-8838 2284-0230 |
| language | English |
| last_indexed | 2024-12-14T10:50:14Z |
| publishDate | 2011-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Biological Research |
| spelling | doaj.art-4de89126e8bb4db48737ffbd6150bb992022-12-21T23:05:15ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302011-01-0184110.4081/jbr.2011.46893836Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)V. VillaA. CorsaroS. ThellungA. SimiM. NizzariM. TonelliV. BoidoA. AcetoT. FlorioThe effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrP<sup>Sc</sup>-like structure affecting the survival of SH-SY5Y cells. Quinacrine and minocycline prevented hPrP90-231-induced toxicity interfering with different mechanisms: protective effects of quinacrine are mediated by the binding to the fragment that abolished hPrP90-231 structural changes and cell internalization, whereas, minocycline reverted MAP kinase neurotoxic signaling exerted by the prion fragment.http://www.pagepressjournals.org/index.php/jbr/article/view/4689prion protein, quinacrine, minocycline |
| spellingShingle | V. Villa A. Corsaro S. Thellung A. Simi M. Nizzari M. Tonelli V. Boido A. Aceto T. Florio Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) Journal of Biological Research prion protein, quinacrine, minocycline |
| title | Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) |
| title_full | Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) |
| title_fullStr | Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) |
| title_full_unstemmed | Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) |
| title_short | Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) |
| title_sort | molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90 231 hprp90 231 |
| topic | prion protein, quinacrine, minocycline |
| url | http://www.pagepressjournals.org/index.php/jbr/article/view/4689 |
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