TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content

TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content

BackgroundTNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5. TRAIL is investigated as a therapeutic agent in clinical trials due to its selective toxicity...

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Main Authors: Sinem Gunalp, Derya Goksu Helvaci, Aysenur Oner, Ahmet Bursalı, Alessandra Conforte, Hüseyin Güner, Gökhan Karakülah, Eva Szegezdi, Duygu Sag
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
TRAIL
death receptors
primary human macrophages
macrophage polarization
macrophage cytotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1209249/full

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