Parasitosis by <i>Fasciola hepatica</i> and Variations in Gut Microbiota in School-Aged Children from Peru
(1) Background: Human fascioliasis is considered an endemic and hyper-endemic disease in the Peruvian Andean valleys. Our objective was to determine variations in the composition of the gut microbiota among children with <i>Fasciola hepatica</i> and children who do not have this parasito...
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MDPI AG
2024-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/2/371 |
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| author | Wilmer Silva-Caso Hugo Carrillo-Ng Miguel Angel Aguilar-Luis Yordi Tarazona-Castro Luis J. Del Valle Carmen Tinco-Valdez Carlos Palomares-Reyes Numan Urteaga Jorge Bazán-Mayra Juana del Valle-Mendoza |
| author_facet | Wilmer Silva-Caso Hugo Carrillo-Ng Miguel Angel Aguilar-Luis Yordi Tarazona-Castro Luis J. Del Valle Carmen Tinco-Valdez Carlos Palomares-Reyes Numan Urteaga Jorge Bazán-Mayra Juana del Valle-Mendoza |
| author_sort | Wilmer Silva-Caso |
| collection | DOAJ |
| description | (1) Background: Human fascioliasis is considered an endemic and hyper-endemic disease in the Peruvian Andean valleys. Our objective was to determine variations in the composition of the gut microbiota among children with <i>Fasciola hepatica</i> and children who do not have this parasitosis. (2) Method: A secondary analysis was performed using fecal samples stored in our biobank. The samples were collected as part of an epidemiological <i>Fasciola hepatica</i> cross-sectional study in children from 4 through 14 years old from a community in Cajamarca, Peru. (3) Results: In a comparison of the bacterial genera that make up the intestinal microbiota between the <i>F. hepatica</i> positive and negative groups, it was found that there are significant differences in the determination of <i>Lactobacillus</i> (<i>p</i> = 0.010, CI: 8.5–61.4), <i>Bacteroides</i> (<i>p</i> = 0.020, CI: 18.5–61.4), <i>Clostridium</i> (<i>p</i> < 0.001, CI: 3.5–36.0), and <i>Bifidobacterium</i> (<i>p</i> = 0.018, CI: 1.1–28.3), with each of these genera being less frequent in children parasitized with <i>F. hepatica</i>. (4) Conclusions: These results show that <i>F. hepatica</i> may be associated with direct or indirect changes in the bacterial population of the intestinal microbiota, particularly affecting three bacterial genera. |
| first_indexed | 2024-03-07T22:20:45Z |
| format | Article |
| id | doaj.art-4de9f84b92e54862a2fea7eb89002ce3 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-07T22:20:45Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-4de9f84b92e54862a2fea7eb89002ce32024-02-23T15:28:21ZengMDPI AGMicroorganisms2076-26072024-02-0112237110.3390/microorganisms12020371Parasitosis by <i>Fasciola hepatica</i> and Variations in Gut Microbiota in School-Aged Children from PeruWilmer Silva-Caso0Hugo Carrillo-Ng1Miguel Angel Aguilar-Luis2Yordi Tarazona-Castro3Luis J. Del Valle4Carmen Tinco-Valdez5Carlos Palomares-Reyes6Numan Urteaga7Jorge Bazán-Mayra8Juana del Valle-Mendoza9Research and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruResearch and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruResearch and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruResearch and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruBarcelona Research Center for Multiscale Science and Engineering, Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya (UPC), 08019 Barcelona, SpainResearch and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruResearch and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, PeruPuesto de Salud Callancas, Dirección Regional de Salud Cajamarca (DIRESA), Cajamarca 60101, PeruLaboratorio Regional de Cajamarca, Dirección Regional de Salud de Cajamarca (DIRESA), Cajamarca 60101, PeruResearch and Innovation Centre, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru(1) Background: Human fascioliasis is considered an endemic and hyper-endemic disease in the Peruvian Andean valleys. Our objective was to determine variations in the composition of the gut microbiota among children with <i>Fasciola hepatica</i> and children who do not have this parasitosis. (2) Method: A secondary analysis was performed using fecal samples stored in our biobank. The samples were collected as part of an epidemiological <i>Fasciola hepatica</i> cross-sectional study in children from 4 through 14 years old from a community in Cajamarca, Peru. (3) Results: In a comparison of the bacterial genera that make up the intestinal microbiota between the <i>F. hepatica</i> positive and negative groups, it was found that there are significant differences in the determination of <i>Lactobacillus</i> (<i>p</i> = 0.010, CI: 8.5–61.4), <i>Bacteroides</i> (<i>p</i> = 0.020, CI: 18.5–61.4), <i>Clostridium</i> (<i>p</i> < 0.001, CI: 3.5–36.0), and <i>Bifidobacterium</i> (<i>p</i> = 0.018, CI: 1.1–28.3), with each of these genera being less frequent in children parasitized with <i>F. hepatica</i>. (4) Conclusions: These results show that <i>F. hepatica</i> may be associated with direct or indirect changes in the bacterial population of the intestinal microbiota, particularly affecting three bacterial genera.https://www.mdpi.com/2076-2607/12/2/371fascioliasisgut microbiotadysbiosis |
| spellingShingle | Wilmer Silva-Caso Hugo Carrillo-Ng Miguel Angel Aguilar-Luis Yordi Tarazona-Castro Luis J. Del Valle Carmen Tinco-Valdez Carlos Palomares-Reyes Numan Urteaga Jorge Bazán-Mayra Juana del Valle-Mendoza Parasitosis by <i>Fasciola hepatica</i> and Variations in Gut Microbiota in School-Aged Children from Peru Microorganisms fascioliasis gut microbiota dysbiosis |
| title | Parasitosis by <i>Fasciola hepatica</i> and Variations in Gut Microbiota in School-Aged Children from Peru |
| title_full | Parasitosis by <i>Fasciola hepatica</i> and Variations in Gut Microbiota in School-Aged Children from Peru |
| title_fullStr | Parasitosis by <i>Fasciola hepatica</i> and Variations in Gut Microbiota in School-Aged Children from Peru |
| title_full_unstemmed | Parasitosis by <i>Fasciola hepatica</i> and Variations in Gut Microbiota in School-Aged Children from Peru |
| title_short | Parasitosis by <i>Fasciola hepatica</i> and Variations in Gut Microbiota in School-Aged Children from Peru |
| title_sort | parasitosis by i fasciola hepatica i and variations in gut microbiota in school aged children from peru |
| topic | fascioliasis gut microbiota dysbiosis |
| url | https://www.mdpi.com/2076-2607/12/2/371 |
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