Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation
Nowadays, allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy that is mainly recommended for hematologic malignancies. However, complications (such as graft-versus-host disease, mucositis, disease relapse, and infections) associated with the HSCT procedure contribute...
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MDPI AG
2021-09-01
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author | Karolina Kaźmierczak-Siedlecka Karolina Skonieczna-Żydecka Jarosław Biliński Giandomenico Roviello Luigi Francesco Iannone Alessandro Atzeni Bartosz Kamil Sobocki Karol Połom |
author_facet | Karolina Kaźmierczak-Siedlecka Karolina Skonieczna-Żydecka Jarosław Biliński Giandomenico Roviello Luigi Francesco Iannone Alessandro Atzeni Bartosz Kamil Sobocki Karol Połom |
author_sort | Karolina Kaźmierczak-Siedlecka |
collection | DOAJ |
description | Nowadays, allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy that is mainly recommended for hematologic malignancies. However, complications (such as graft-versus-host disease, mucositis, disease relapse, and infections) associated with the HSCT procedure contribute to the development of gut microbiota imbalance, gut-barrier disruption, and increased intestinal permeability. In the present narrative review, the crosstalk between gut microbiota products and intestinal homeostasis is discussed. Notably, gut-microbiota-related aspects have an impact on patients’ clinical outcomes and overall survival. In accordance with the most recent published data, gut microbiota is crucial for the treatment effectiveness of many diseases, not only gastrointestinal cancers but also hematologic malignancies. Therefore, it is necessary to indicate a therapeutic method allowing to modulate gut microbiota in HSCT recipients. Currently, fecal microbiota transplantation (FMT) is the most innovative method used to alter/restore gut microbiota composition, as well as modulate its activity. Despite the fact that some previous data have shown promising results, the knowledge regarding FMT in HSCT is still strongly limited, except for the treatment of <i>Clostridium difficile</i> infection. Additionally, administration of prebiotics, probiotics, synbiotics, and postbiotics can also modify gut microbiota; however, this strategy should be considered carefully due to the high risk of fungemia/septicemia (especially in case of fungal probiotics). |
first_indexed | 2024-03-10T07:50:13Z |
format | Article |
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issn | 2072-6694 |
language | English |
last_indexed | 2024-03-10T07:50:13Z |
publishDate | 2021-09-01 |
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series | Cancers |
spelling | doaj.art-4ded0db15ce64ab59b8cf404eaea0d4a2023-11-22T12:18:45ZengMDPI AGCancers2072-66942021-09-011318466510.3390/cancers13184665Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell TransplantationKarolina Kaźmierczak-Siedlecka0Karolina Skonieczna-Żydecka1Jarosław Biliński2Giandomenico Roviello3Luigi Francesco Iannone4Alessandro Atzeni5Bartosz Kamil Sobocki6Karol Połom7Department of Surgical Oncology, Medical University of Gdansk, 80-214 Gdańsk, PolandDepartment of Biochemical Sciences, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandDepartment of Hematology, Transplantology and Internal Medicine, Medical University of Warsaw, 02-097 Warszawa, PolandDepartment of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, 50139 Florence, ItalyDepartment of Health Science, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyHuman Nutrition Unit, Department of Biochemistry and Biotechnology, Rovira i Virgili University, Faculty of Medicine and Health Sciences, Campus Vapor Vell, 43210 Reus, SpainInternational Research Agenda 3P—Medicine Laboratory, Medical University of Gdansk, 80-214 Gdańsk, PolandDepartment of Surgical Oncology, Medical University of Gdansk, 80-214 Gdańsk, PolandNowadays, allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy that is mainly recommended for hematologic malignancies. However, complications (such as graft-versus-host disease, mucositis, disease relapse, and infections) associated with the HSCT procedure contribute to the development of gut microbiota imbalance, gut-barrier disruption, and increased intestinal permeability. In the present narrative review, the crosstalk between gut microbiota products and intestinal homeostasis is discussed. Notably, gut-microbiota-related aspects have an impact on patients’ clinical outcomes and overall survival. In accordance with the most recent published data, gut microbiota is crucial for the treatment effectiveness of many diseases, not only gastrointestinal cancers but also hematologic malignancies. Therefore, it is necessary to indicate a therapeutic method allowing to modulate gut microbiota in HSCT recipients. Currently, fecal microbiota transplantation (FMT) is the most innovative method used to alter/restore gut microbiota composition, as well as modulate its activity. Despite the fact that some previous data have shown promising results, the knowledge regarding FMT in HSCT is still strongly limited, except for the treatment of <i>Clostridium difficile</i> infection. Additionally, administration of prebiotics, probiotics, synbiotics, and postbiotics can also modify gut microbiota; however, this strategy should be considered carefully due to the high risk of fungemia/septicemia (especially in case of fungal probiotics).https://www.mdpi.com/2072-6694/13/18/4665allogenic hematopoietic stem cell transplantationfecal microbiota transplantationprebioticsprobioticssynbioticspostbiotics |
spellingShingle | Karolina Kaźmierczak-Siedlecka Karolina Skonieczna-Żydecka Jarosław Biliński Giandomenico Roviello Luigi Francesco Iannone Alessandro Atzeni Bartosz Kamil Sobocki Karol Połom Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation Cancers allogenic hematopoietic stem cell transplantation fecal microbiota transplantation prebiotics probiotics synbiotics postbiotics |
title | Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation |
title_full | Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation |
title_fullStr | Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation |
title_full_unstemmed | Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation |
title_short | Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation |
title_sort | gut microbiome modulation and faecal microbiota transplantation following allogenic hematopoietic stem cell transplantation |
topic | allogenic hematopoietic stem cell transplantation fecal microbiota transplantation prebiotics probiotics synbiotics postbiotics |
url | https://www.mdpi.com/2072-6694/13/18/4665 |
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