Somatosensory Stimulus Intensity Encoding in Borderline Personality Disorder
Borderline Personality Disorder (BPD) is clinically characterized by emotional instability, interpersonal disturbances and dysfunctional behavior such as non-suicidal self-injury (NSSI). During NSSI, patients with BPD typically report analgesic or hypoalgesic phenomena, and pain perception and pain...
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2018.01853/full |
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| author | Kathrin Malejko Dominik Neff Rebecca C. Brown Paul L. Plener Paul L. Plener Martina Bonenberger Birgit Abler Georg Grön Heiko Graf |
| author_facet | Kathrin Malejko Dominik Neff Rebecca C. Brown Paul L. Plener Paul L. Plener Martina Bonenberger Birgit Abler Georg Grön Heiko Graf |
| author_sort | Kathrin Malejko |
| collection | DOAJ |
| description | Borderline Personality Disorder (BPD) is clinically characterized by emotional instability, interpersonal disturbances and dysfunctional behavior such as non-suicidal self-injury (NSSI). During NSSI, patients with BPD typically report analgesic or hypoalgesic phenomena, and pain perception and pain processing in BPD have been repeatedly investigated. Most of the studies so far focused on affective-motivational and cognitive-evaluative neural components of pain within categorial study designs. By contrast, rather basic somatosensory aspects such as neural intensity-encoding of somatosensory stimuli were not examined in further details. Thus, we investigated patients with BPD and healthy controls (HC) by functional magnetic resonance imaging (fMRI) during an unpleasant sensory stimulation task with parametrically increasing stimulus intensities. 15 females diagnosed with BPD and 15 HCs were investigated with fMRI during four individually adjusted levels of electrical stimulus intensities. Ratings of stimulus intensity were assessed by button presses during fMRI. fMRI-data were analyzed by analyses of variances (ANOVA) at a statistical threshold of p < 0.05 FWE-corrected on cluster level. Subjective ratings of stimulus intensities were alike between BPD and HC, and intensity levels identified with equal accuracy. Significant intensity-encoding neural activations were observed within the primary and secondary somtasensory cortex, the posterior insula, the posterior midcingulate cortex (pMCC) and the supplementary motor area (SMA) in both, HC and BPD. Notably, there were no significant between-groups differences in intensity-encoding neural activations, even at lowered significance thresholds. Present results suggest a similar neural somatosensory stimulus intensity encoding in BPD as previously observed on a behavioral level. The alterations in neural affective-motivational or cognitive-evaluative components reported so far may be restricted to pain rather than unpleasant stimulus processing and were absent in our study. |
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| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-20T12:16:34Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-4df10571670f4c8c999d35951e2176472022-12-21T19:41:06ZengFrontiers Media S.A.Frontiers in Psychology1664-10782018-10-01910.3389/fpsyg.2018.01853404449Somatosensory Stimulus Intensity Encoding in Borderline Personality DisorderKathrin Malejko0Dominik Neff1Rebecca C. Brown2Paul L. Plener3Paul L. Plener4Martina Bonenberger5Birgit Abler6Georg Grön7Heiko Graf8Department of Psychiatry and Psychotherapy III, Ulm University, Ulm, GermanyDepartment of Psychiatry and Psychotherapy III, Ulm University, Ulm, GermanyDepartment of Child and Adolescent Psychiatry and Psychotherapy, Ulm University, Ulm, GermanyDepartment of Child and Adolescent Psychiatry and Psychotherapy, Ulm University, Ulm, GermanyDepartment of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, AustriaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Ulm University, Ulm, GermanyDepartment of Psychiatry and Psychotherapy III, Ulm University, Ulm, GermanyDepartment of Psychiatry and Psychotherapy III, Ulm University, Ulm, GermanyDepartment of Psychiatry and Psychotherapy III, Ulm University, Ulm, GermanyBorderline Personality Disorder (BPD) is clinically characterized by emotional instability, interpersonal disturbances and dysfunctional behavior such as non-suicidal self-injury (NSSI). During NSSI, patients with BPD typically report analgesic or hypoalgesic phenomena, and pain perception and pain processing in BPD have been repeatedly investigated. Most of the studies so far focused on affective-motivational and cognitive-evaluative neural components of pain within categorial study designs. By contrast, rather basic somatosensory aspects such as neural intensity-encoding of somatosensory stimuli were not examined in further details. Thus, we investigated patients with BPD and healthy controls (HC) by functional magnetic resonance imaging (fMRI) during an unpleasant sensory stimulation task with parametrically increasing stimulus intensities. 15 females diagnosed with BPD and 15 HCs were investigated with fMRI during four individually adjusted levels of electrical stimulus intensities. Ratings of stimulus intensity were assessed by button presses during fMRI. fMRI-data were analyzed by analyses of variances (ANOVA) at a statistical threshold of p < 0.05 FWE-corrected on cluster level. Subjective ratings of stimulus intensities were alike between BPD and HC, and intensity levels identified with equal accuracy. Significant intensity-encoding neural activations were observed within the primary and secondary somtasensory cortex, the posterior insula, the posterior midcingulate cortex (pMCC) and the supplementary motor area (SMA) in both, HC and BPD. Notably, there were no significant between-groups differences in intensity-encoding neural activations, even at lowered significance thresholds. Present results suggest a similar neural somatosensory stimulus intensity encoding in BPD as previously observed on a behavioral level. The alterations in neural affective-motivational or cognitive-evaluative components reported so far may be restricted to pain rather than unpleasant stimulus processing and were absent in our study.https://www.frontiersin.org/article/10.3389/fpsyg.2018.01853/fullpainparametricborderlinefMRIstimulus processing |
| spellingShingle | Kathrin Malejko Dominik Neff Rebecca C. Brown Paul L. Plener Paul L. Plener Martina Bonenberger Birgit Abler Georg Grön Heiko Graf Somatosensory Stimulus Intensity Encoding in Borderline Personality Disorder Frontiers in Psychology pain parametric borderline fMRI stimulus processing |
| title | Somatosensory Stimulus Intensity Encoding in Borderline Personality Disorder |
| title_full | Somatosensory Stimulus Intensity Encoding in Borderline Personality Disorder |
| title_fullStr | Somatosensory Stimulus Intensity Encoding in Borderline Personality Disorder |
| title_full_unstemmed | Somatosensory Stimulus Intensity Encoding in Borderline Personality Disorder |
| title_short | Somatosensory Stimulus Intensity Encoding in Borderline Personality Disorder |
| title_sort | somatosensory stimulus intensity encoding in borderline personality disorder |
| topic | pain parametric borderline fMRI stimulus processing |
| url | https://www.frontiersin.org/article/10.3389/fpsyg.2018.01853/full |
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