Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like.

Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like.

BACKGROUND: Amyloid β (Aβ), a causative peptide of Alzheimer's disease, is generated by intracellular metabolism of amyloid β-protein precursor (APP). In general, mature APP (mAPP, N- and O-glycosylated form) is subject to successive cleavages by α- or β-, and γ-secretases in the late protein s...

Full description

Bibliographic Details
Main Authors: Yuhki Saito, Mayu Akiyama, Yoichi Araki, Akio Sumioka, Maki Shiono, Hidenori Taru, Tadashi Nakaya, Tohru Yamamoto, Toshiharu Suzuki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3139598?pdf=render

Internet

http://europepmc.org/articles/PMC3139598?pdf=render

Similar Items