Design and Synthesis of Novel Tetrapeptide Analogues as New Cytotoxic Agents
New series of compounds based on a tetrapeptide scaffold containing methyl sulfonyl group at the para position of a phenyl ring were synthesized and their cytotoxic activities were examined against several human cancer cell lines including MCF-7 (breast cancer Cell Line), HepG2 (human liver cancer C...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2017-09-01
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| Series: | Trends in Peptide and Protein Sciences |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/protein/article/view/17476 |
| _version_ | 1818985608234663936 |
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| author | Mohammad Ali Ahmaditaba Mohammad Hassan Houshdar Tehrani Afshin Zarghi Sorayya Shahosseini Sara Hariri |
| author_facet | Mohammad Ali Ahmaditaba Mohammad Hassan Houshdar Tehrani Afshin Zarghi Sorayya Shahosseini Sara Hariri |
| author_sort | Mohammad Ali Ahmaditaba |
| collection | DOAJ |
| description | New series of compounds based on a tetrapeptide scaffold containing methyl sulfonyl group at the para position of a phenyl ring were synthesized and their cytotoxic activities were examined against several human cancer cell lines including MCF-7 (breast cancer Cell Line), HepG2 (human liver cancer Cell Line), HT-29 (Human Colorectal Adenocarcinoma Cell Line) and A549 (adenocarcinomic human alveolar basal epithelial cells) using MTT assay. Based on the results, among the synthesized peptides, 5e, 5f, 1g, and 3g were the most potent cytotoxic compounds that were more toxic than the reference compound, Celecoxib, against the tested cell lines. These compounds could be candidate for finding cytotoxic agents with new peptide scaffolds which show COX-2 inhibitory activity as well.
HIGHLIGHTS
•A group of tetrapeptides was reported as COX-2 inhibitors with antiproliferative activity.
•New tetrapeptides containing methyl sulfonyl group at the para position of a phenyl ring were synthesized.
•Some of novel compounds exhibited more potent cytotoxic effect than Celecoxib as the reference. |
| first_indexed | 2024-12-20T18:37:36Z |
| format | Article |
| id | doaj.art-4df29774617a4e268a04ba981607bc8a |
| institution | Directory Open Access Journal |
| issn | 2538-2446 |
| language | English |
| last_indexed | 2024-12-20T18:37:36Z |
| publishDate | 2017-09-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Trends in Peptide and Protein Sciences |
| spelling | doaj.art-4df29774617a4e268a04ba981607bc8a2022-12-21T19:29:53ZengShahid Beheshti University of Medical SciencesTrends in Peptide and Protein Sciences2538-24462017-09-011416717610.22037/tpps.v1i4.1747617476Design and Synthesis of Novel Tetrapeptide Analogues as New Cytotoxic AgentsMohammad Ali AhmaditabaMohammad Hassan Houshdar TehraniAfshin ZarghiSorayya ShahosseiniSara HaririNew series of compounds based on a tetrapeptide scaffold containing methyl sulfonyl group at the para position of a phenyl ring were synthesized and their cytotoxic activities were examined against several human cancer cell lines including MCF-7 (breast cancer Cell Line), HepG2 (human liver cancer Cell Line), HT-29 (Human Colorectal Adenocarcinoma Cell Line) and A549 (adenocarcinomic human alveolar basal epithelial cells) using MTT assay. Based on the results, among the synthesized peptides, 5e, 5f, 1g, and 3g were the most potent cytotoxic compounds that were more toxic than the reference compound, Celecoxib, against the tested cell lines. These compounds could be candidate for finding cytotoxic agents with new peptide scaffolds which show COX-2 inhibitory activity as well. HIGHLIGHTS •A group of tetrapeptides was reported as COX-2 inhibitors with antiproliferative activity. •New tetrapeptides containing methyl sulfonyl group at the para position of a phenyl ring were synthesized. •Some of novel compounds exhibited more potent cytotoxic effect than Celecoxib as the reference.https://journals.sbmu.ac.ir/protein/article/view/17476cytotoxic activitymethyl sulfonyl groupmttsynthesistetrapeptide scaffold |
| spellingShingle | Mohammad Ali Ahmaditaba Mohammad Hassan Houshdar Tehrani Afshin Zarghi Sorayya Shahosseini Sara Hariri Design and Synthesis of Novel Tetrapeptide Analogues as New Cytotoxic Agents Trends in Peptide and Protein Sciences cytotoxic activity methyl sulfonyl group mtt synthesis tetrapeptide scaffold |
| title | Design and Synthesis of Novel Tetrapeptide Analogues as New Cytotoxic Agents |
| title_full | Design and Synthesis of Novel Tetrapeptide Analogues as New Cytotoxic Agents |
| title_fullStr | Design and Synthesis of Novel Tetrapeptide Analogues as New Cytotoxic Agents |
| title_full_unstemmed | Design and Synthesis of Novel Tetrapeptide Analogues as New Cytotoxic Agents |
| title_short | Design and Synthesis of Novel Tetrapeptide Analogues as New Cytotoxic Agents |
| title_sort | design and synthesis of novel tetrapeptide analogues as new cytotoxic agents |
| topic | cytotoxic activity methyl sulfonyl group mtt synthesis tetrapeptide scaffold |
| url | https://journals.sbmu.ac.ir/protein/article/view/17476 |
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