Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis
Objective: To describe postprandial lipemia in patients with rheumatoid arthritis (RA) and to analyze its association with subclinical atherosclerosis measured as carotid intima-media thickness (cIMT). Methods: We performed an observational study of 40 patients with RA and 40 sex and age-matched con...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/8/2483 |
| _version_ | 1797560464374235136 |
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| author | Natalia Mena-Vázquez Marta Rojas-Gimenez Francisco Gabriel Jimenez Nuñez Sara Manrique-Arija José Rioja Patricia Ruiz-Limón Inmaculada Ureña Manuel Castro-Cabezas Pedro Valdivielso Antonio Fernández-Nebro |
| author_facet | Natalia Mena-Vázquez Marta Rojas-Gimenez Francisco Gabriel Jimenez Nuñez Sara Manrique-Arija José Rioja Patricia Ruiz-Limón Inmaculada Ureña Manuel Castro-Cabezas Pedro Valdivielso Antonio Fernández-Nebro |
| author_sort | Natalia Mena-Vázquez |
| collection | DOAJ |
| description | Objective: To describe postprandial lipemia in patients with rheumatoid arthritis (RA) and to analyze its association with subclinical atherosclerosis measured as carotid intima-media thickness (cIMT). Methods: We performed an observational study of 40 patients with RA and 40 sex and age-matched controls. Patients with dyslipidemia were excluded. Pathologically increased cIMT was defined as a carotid thickness greater than the 90th percentile (>p90) for age and sex. Fasting and postprandial plasma lipids, cholesterol, triglycerides, apolipoprotein B48 (ApoB48), and total ApoB were evaluated. The other variables included were clinical and laboratory values, Framingham score, and the 28-joint Disease Activity Score (DAS28). Two multivariate models were constructed to identify factors associated with pathologic cIMT in patients with RA. Results: Fasting lipid values were similar in patients with RA and controls, although those of postprandial ApoB48 were higher (median (IQR), 14.4 (10.8–12.1) vs. 12.1 (2.3–9,8); <i>p</i> = 0.042). Pathologic cIMT was recorded in 10 patients with RA (25%) and nine controls (22.5%). In patients with RA, pathologic cIMT was associated with postprandial ApoB48 (OR (95% CI), 1.15 (1.0–1.3)) and total ApoB (OR [95% CI], 1.12 [1.1–1.2]). The second model revealed a mean increase of 0.256 mm for cIMT in patients with elevated anticitrullinated protein antibodies (ACPAs). Conclusion: Postprandial ApoB48 levels in patients with RA are higher than in controls. Postprandial ApoB48 and total ApoB levels and markers of severity, such as ACPAs, are associated with pathologic cIMT in patients with RA. Our findings could indicate that these atherogenic particles have a negative effect on the endothelium. |
| first_indexed | 2024-03-10T18:00:55Z |
| format | Article |
| id | doaj.art-4df4524ce7774b43a08305ead62d158b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:00:55Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-4df4524ce7774b43a08305ead62d158b2023-11-20T08:51:46ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0198248310.3390/jcm9082483Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid ArthritisNatalia Mena-Vázquez0Marta Rojas-Gimenez1Francisco Gabriel Jimenez Nuñez2Sara Manrique-Arija3José Rioja4Patricia Ruiz-Limón5Inmaculada Ureña6Manuel Castro-Cabezas7Pedro Valdivielso8Antonio Fernández-Nebro9The Institute of Biomedical Research in Malaga (IBIMA), 29010 Málaga, SpainUGC de Reumatología, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofia, 14004 Córdoba, SpainThe Institute of Biomedical Research in Malaga (IBIMA), 29010 Málaga, SpainThe Institute of Biomedical Research in Malaga (IBIMA), 29010 Málaga, SpainThe Institute of Biomedical Research in Malaga (IBIMA), 29010 Málaga, SpainThe Institute of Biomedical Research in Malaga (IBIMA), 29010 Málaga, SpainThe Institute of Biomedical Research in Malaga (IBIMA), 29010 Málaga, SpainDepartment of Internal Medicine, Franciscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM Rotterdam, The NetherlandsThe Institute of Biomedical Research in Malaga (IBIMA), 29010 Málaga, SpainThe Institute of Biomedical Research in Malaga (IBIMA), 29010 Málaga, SpainObjective: To describe postprandial lipemia in patients with rheumatoid arthritis (RA) and to analyze its association with subclinical atherosclerosis measured as carotid intima-media thickness (cIMT). Methods: We performed an observational study of 40 patients with RA and 40 sex and age-matched controls. Patients with dyslipidemia were excluded. Pathologically increased cIMT was defined as a carotid thickness greater than the 90th percentile (>p90) for age and sex. Fasting and postprandial plasma lipids, cholesterol, triglycerides, apolipoprotein B48 (ApoB48), and total ApoB were evaluated. The other variables included were clinical and laboratory values, Framingham score, and the 28-joint Disease Activity Score (DAS28). Two multivariate models were constructed to identify factors associated with pathologic cIMT in patients with RA. Results: Fasting lipid values were similar in patients with RA and controls, although those of postprandial ApoB48 were higher (median (IQR), 14.4 (10.8–12.1) vs. 12.1 (2.3–9,8); <i>p</i> = 0.042). Pathologic cIMT was recorded in 10 patients with RA (25%) and nine controls (22.5%). In patients with RA, pathologic cIMT was associated with postprandial ApoB48 (OR (95% CI), 1.15 (1.0–1.3)) and total ApoB (OR [95% CI], 1.12 [1.1–1.2]). The second model revealed a mean increase of 0.256 mm for cIMT in patients with elevated anticitrullinated protein antibodies (ACPAs). Conclusion: Postprandial ApoB48 levels in patients with RA are higher than in controls. Postprandial ApoB48 and total ApoB levels and markers of severity, such as ACPAs, are associated with pathologic cIMT in patients with RA. Our findings could indicate that these atherogenic particles have a negative effect on the endothelium.https://www.mdpi.com/2077-0383/9/8/2483rheumatoid arthritispostprandial lipemiaapolipoprotein B48subclinical atherosclerosis |
| spellingShingle | Natalia Mena-Vázquez Marta Rojas-Gimenez Francisco Gabriel Jimenez Nuñez Sara Manrique-Arija José Rioja Patricia Ruiz-Limón Inmaculada Ureña Manuel Castro-Cabezas Pedro Valdivielso Antonio Fernández-Nebro Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis Journal of Clinical Medicine rheumatoid arthritis postprandial lipemia apolipoprotein B48 subclinical atherosclerosis |
| title | Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_full | Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_fullStr | Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_full_unstemmed | Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_short | Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis |
| title_sort | postprandial apolipoprotein b48 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis |
| topic | rheumatoid arthritis postprandial lipemia apolipoprotein B48 subclinical atherosclerosis |
| url | https://www.mdpi.com/2077-0383/9/8/2483 |
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