Solid Lipid Nanoparticles
Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, and prolong the circulation time of various drugs. SLNs have been applied in the oral, parenteral, transder...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Encyclopedia |
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| Online Access: | https://www.mdpi.com/2673-8392/2/2/63 |
| _version_ | 1797487900996141056 |
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| author | Thi-Thao-Linh Nguyen Van-An Duong |
| author_facet | Thi-Thao-Linh Nguyen Van-An Duong |
| author_sort | Thi-Thao-Linh Nguyen |
| collection | DOAJ |
| description | Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, and prolong the circulation time of various drugs. SLNs have been applied in the oral, parenteral, transdermal, intranasal, ocular, and pulmonary drug delivery of different drugs, with enhanced safety, bioavailability, and overall therapeutic effects. In this entry, the authors summarize the primary features of SLNs, methods to prepare SLNs, and recent applications of SLNs in drug delivery. Owing to their advantages, SLNs are potential drug delivery systems to improve the management of various diseases and will, soon, be available for clinical use. |
| first_indexed | 2024-03-09T23:55:21Z |
| format | Article |
| id | doaj.art-4df8f82ff0c34b9ca761a21b2583c536 |
| institution | Directory Open Access Journal |
| issn | 2673-8392 |
| language | English |
| last_indexed | 2024-03-09T23:55:21Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Encyclopedia |
| spelling | doaj.art-4df8f82ff0c34b9ca761a21b2583c5362023-11-23T16:26:23ZengMDPI AGEncyclopedia2673-83922022-05-012295297310.3390/encyclopedia2020063Solid Lipid NanoparticlesThi-Thao-Linh Nguyen0Van-An Duong1College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, KoreaCollege of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, KoreaSolid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, and prolong the circulation time of various drugs. SLNs have been applied in the oral, parenteral, transdermal, intranasal, ocular, and pulmonary drug delivery of different drugs, with enhanced safety, bioavailability, and overall therapeutic effects. In this entry, the authors summarize the primary features of SLNs, methods to prepare SLNs, and recent applications of SLNs in drug delivery. Owing to their advantages, SLNs are potential drug delivery systems to improve the management of various diseases and will, soon, be available for clinical use.https://www.mdpi.com/2673-8392/2/2/63solid lipid nanoparticlesnanostructured lipid carriersdrug deliveryoralparenteraltransdermal |
| spellingShingle | Thi-Thao-Linh Nguyen Van-An Duong Solid Lipid Nanoparticles Encyclopedia solid lipid nanoparticles nanostructured lipid carriers drug delivery oral parenteral transdermal |
| title | Solid Lipid Nanoparticles |
| title_full | Solid Lipid Nanoparticles |
| title_fullStr | Solid Lipid Nanoparticles |
| title_full_unstemmed | Solid Lipid Nanoparticles |
| title_short | Solid Lipid Nanoparticles |
| title_sort | solid lipid nanoparticles |
| topic | solid lipid nanoparticles nanostructured lipid carriers drug delivery oral parenteral transdermal |
| url | https://www.mdpi.com/2673-8392/2/2/63 |
| work_keys_str_mv | AT thithaolinhnguyen solidlipidnanoparticles AT vananduong solidlipidnanoparticles |