Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines

Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines

Introduction: Daunorubicin and doxorubicin, two anthracycline polyketides produced by S. peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of producing improved derivatives with reduced side effec...

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Bibliographic Details
Main Authors: Mandy B. Hulst, Le Zhang, Helga U. van der Heul, Chao Du, Somayah S. Elsayed, Arina Koroleva, Thadee Grocholski, Dennis P. A. Wander, Mikko Metsä-Ketelä, Jacques J. C. Neefjes, Gilles P. van Wezel
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
doxorubicin
anthracyclines
anticancer
metabolic engineering
biosynthesis
Streptomyces
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1363803/full

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