Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and Celastrol
With the progress of medicine, especially in the last century, life expectancy increased considerably. As a result, age-related diseases also increased, especially malignancies and degenerative diseases of the central nervous system. The incidence and prevalence of neurodegenerative diseases steadil...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/746 |
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| author | Kristina Pilipović Renata Jurišić Grubešić Petra Dolenec Natalia Kučić Lea Juretić Jasenka Mršić-Pelčić |
| author_facet | Kristina Pilipović Renata Jurišić Grubešić Petra Dolenec Natalia Kučić Lea Juretić Jasenka Mršić-Pelčić |
| author_sort | Kristina Pilipović |
| collection | DOAJ |
| description | With the progress of medicine, especially in the last century, life expectancy increased considerably. As a result, age-related diseases also increased, especially malignancies and degenerative diseases of the central nervous system. The incidence and prevalence of neurodegenerative diseases steadily increased over the years, but despite efforts to uncover the pathophysiological processes behind these conditions, they remain elusive. Among the many theories, oxidative stress was proposed to be involved in neurodegenerative processes and to play an important role in the morbidity and progression of various neurodegenerative disorders. Accordingly, a number of studies discovered the potential of natural plant constituents to have significant antioxidant activity. This review focused on several plant-based antioxidants that showed promising results in the prevention and treatment of neurodegenerative diseases. <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and celastrol, a chemical compound isolated from the root extracts of <i>Tripterygium wilfordii</i> and <i>T. regelii</i>, are all known to be rich in antioxidant polyphenols. |
| first_indexed | 2024-03-11T06:59:26Z |
| format | Article |
| id | doaj.art-4dfac5884ca44b33aabbe58d62a286b6 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T06:59:26Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-4dfac5884ca44b33aabbe58d62a286b62023-11-17T09:19:11ZengMDPI AGAntioxidants2076-39212023-03-0112374610.3390/antiox12030746Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and CelastrolKristina Pilipović0Renata Jurišić Grubešić1Petra Dolenec2Natalia Kučić3Lea Juretić4Jasenka Mršić-Pelčić5Department of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, HR-51000 Rijeka, CroatiaDepartment of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, HR-51000 Rijeka, CroatiaDepartment of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, HR-51000 Rijeka, CroatiaDepartment of Physiology and Immunology, Faculty of Medicine, University of Rijeka, HR-51000 Rijeka, CroatiaDepartment of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, HR-51000 Rijeka, CroatiaDepartment of Basic and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Rijeka, HR-51000 Rijeka, CroatiaWith the progress of medicine, especially in the last century, life expectancy increased considerably. As a result, age-related diseases also increased, especially malignancies and degenerative diseases of the central nervous system. The incidence and prevalence of neurodegenerative diseases steadily increased over the years, but despite efforts to uncover the pathophysiological processes behind these conditions, they remain elusive. Among the many theories, oxidative stress was proposed to be involved in neurodegenerative processes and to play an important role in the morbidity and progression of various neurodegenerative disorders. Accordingly, a number of studies discovered the potential of natural plant constituents to have significant antioxidant activity. This review focused on several plant-based antioxidants that showed promising results in the prevention and treatment of neurodegenerative diseases. <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and celastrol, a chemical compound isolated from the root extracts of <i>Tripterygium wilfordii</i> and <i>T. regelii</i>, are all known to be rich in antioxidant polyphenols.https://www.mdpi.com/2076-3921/12/3/746neurodegenerative diseasesoxidative stressneuroinflammation<i>Laurus nobilis</i><i>Aronia melanocarpa</i>celastrol |
| spellingShingle | Kristina Pilipović Renata Jurišić Grubešić Petra Dolenec Natalia Kučić Lea Juretić Jasenka Mršić-Pelčić Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and Celastrol Antioxidants neurodegenerative diseases oxidative stress neuroinflammation <i>Laurus nobilis</i> <i>Aronia melanocarpa</i> celastrol |
| title | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and Celastrol |
| title_full | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and Celastrol |
| title_fullStr | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and Celastrol |
| title_full_unstemmed | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and Celastrol |
| title_short | Plant-Based Antioxidants for Prevention and Treatment of Neurodegenerative Diseases: Phytotherapeutic Potential of <i>Laurus nobilis</i>, <i>Aronia melanocarpa</i>, and Celastrol |
| title_sort | plant based antioxidants for prevention and treatment of neurodegenerative diseases phytotherapeutic potential of i laurus nobilis i i aronia melanocarpa i and celastrol |
| topic | neurodegenerative diseases oxidative stress neuroinflammation <i>Laurus nobilis</i> <i>Aronia melanocarpa</i> celastrol |
| url | https://www.mdpi.com/2076-3921/12/3/746 |
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