Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach
Background: Osteoarthritis (OA), also known as degenerative arthritis, is the leading cause of chronic disability in elderly. Although, it is a process of progressive deterioration of articular cartilage with ageing which involves numerous risk factors, it is conceivable that oxidative stress mediat...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2015-04-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/12274 |
| _version_ | 1818162072409604096 |
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| author | Jusmita Dutta |
| author_facet | Jusmita Dutta |
| author_sort | Jusmita Dutta |
| collection | DOAJ |
| description | Background: Osteoarthritis (OA), also known as degenerative arthritis, is the leading cause of chronic disability in elderly. Although, it is a process of progressive deterioration of articular cartilage with ageing which involves numerous risk factors, it is conceivable that oxidative stress mediated electrolyte imbalance may have a crucial role in the development of hypertension risk in OA elderly.
Aims & objective: The present study was designed to assess the association of oxidative stress and altered serum electrolyte levels in OA elderly patients and to determine their effect in predicting hypertension (HT) risk.
Methods: Total antioxidant activity (TAA), lipid peroxidation (malondialdehyde; MDA) and serum mineral (Na+, K+, Mg2+ and Ca2+) levels were estimated in 40 OA elderly patients by using standard methods and statistically compared it with that of 40 healthy normal individuals of same age group (55-70 years).
Result: Plasma TAA, serum potassium, magnesium and calcium levels were significantly low in patient group (p<0.05) as compared to healthy controls whereas erythrocyte MDA levels were significantly high in OA subjects. However, serum sodium levels were increased insignificantly (p<0.1) in OA subjects.
Conclusion: Our findings indicate that oxidative stress plays a significant role in shaping the OA older population to develop future hypertension, characterized by altered serum minerals levels. Therefore, consumption of diet rich in antioxidants, proteins and minerals with low dietary salt should be increased with senescence in order to prevent disease complexity. |
| first_indexed | 2024-12-11T16:27:51Z |
| format | Article |
| id | doaj.art-4dfbd03ea0814328b2cfab4e0136c84c |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-11T16:27:51Z |
| publishDate | 2015-04-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-4dfbd03ea0814328b2cfab4e0136c84c2022-12-22T00:58:41ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762015-04-01652630https://doi.org/10.3126/ajms.v6i5.12274Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approachJusmita Dutta 0Associate Professor, Department of Biochemistry, People’s College of Medical Sciences & Research Centre People’s University, Bhopal 462037Background: Osteoarthritis (OA), also known as degenerative arthritis, is the leading cause of chronic disability in elderly. Although, it is a process of progressive deterioration of articular cartilage with ageing which involves numerous risk factors, it is conceivable that oxidative stress mediated electrolyte imbalance may have a crucial role in the development of hypertension risk in OA elderly. Aims & objective: The present study was designed to assess the association of oxidative stress and altered serum electrolyte levels in OA elderly patients and to determine their effect in predicting hypertension (HT) risk. Methods: Total antioxidant activity (TAA), lipid peroxidation (malondialdehyde; MDA) and serum mineral (Na+, K+, Mg2+ and Ca2+) levels were estimated in 40 OA elderly patients by using standard methods and statistically compared it with that of 40 healthy normal individuals of same age group (55-70 years). Result: Plasma TAA, serum potassium, magnesium and calcium levels were significantly low in patient group (p<0.05) as compared to healthy controls whereas erythrocyte MDA levels were significantly high in OA subjects. However, serum sodium levels were increased insignificantly (p<0.1) in OA subjects. Conclusion: Our findings indicate that oxidative stress plays a significant role in shaping the OA older population to develop future hypertension, characterized by altered serum minerals levels. Therefore, consumption of diet rich in antioxidants, proteins and minerals with low dietary salt should be increased with senescence in order to prevent disease complexity.https://www.nepjol.info/index.php/AJMS/article/view/12274elderlytotal antioxidant activitypotassiummagnesiummalondialdehyde |
| spellingShingle | Jusmita Dutta Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach Asian Journal of Medical Sciences elderly total antioxidant activity potassium magnesium malondialdehyde |
| title | Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach |
| title_full | Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach |
| title_fullStr | Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach |
| title_full_unstemmed | Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach |
| title_short | Oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients: A clinical approach |
| title_sort | oxidative stress mediated electrolyte imbalance in 30 known cases of knee osteoarthritis patients a clinical approach |
| topic | elderly total antioxidant activity potassium magnesium malondialdehyde |
| url | https://www.nepjol.info/index.php/AJMS/article/view/12274 |
| work_keys_str_mv | AT jusmitadutta oxidativestressmediatedelectrolyteimbalancein30knowncasesofkneeosteoarthritispatientsaclinicalapproach |