Cognitive decline in patients with essential tremor
Essential tremor (ET) is a heterogeneous disease with a high prevalence and disability. Traditionally, the disease was considered benign with the presence of tremor, the severity of which increases during the observation period. The severity of trembling varies widely from mild, not requiring therap...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2023-07-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/840 |
| _version_ | 1797694654163976192 |
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| author | M. M. Ermakova Z. A. Zalyalova |
| author_facet | M. M. Ermakova Z. A. Zalyalova |
| author_sort | M. M. Ermakova |
| collection | DOAJ |
| description | Essential tremor (ET) is a heterogeneous disease with a high prevalence and disability. Traditionally, the disease was considered benign with the presence of tremor, the severity of which increases during the observation period. The severity of trembling varies widely from mild, not requiring therapy, to disabling. That is making difficulties to assess the prevalence of the disease. However, disability in patients with ET can occur not only due to the severity of tremor.The underestimated side of the disease, despite a long history of study, remains non-motor manifestations, including cognitive decline. Cognitive decline in essential tremor, compared with the general population, has a greater risk of transformation into dementia. In patients with ET, in comparison with other cognitive domains, executive functions are predominantly affected. Patients are also characterized by low awareness and concern about changes in intelligence. In the study of the brain using voxel morphometry, a heterogeneous group of changes that contradict each other was revealed. Most often, a change in the density of the cortex of different parts of the brain is detected in comparison with the control group. The most affected area of the brain is the precuneus. This may explain the executive dysfunction in patients and highlight the likely neurodegenerative nature of essential tremor. The absence of preventive therapy, the high incidence of changes in intelligence emphasizes the need for close monitoring of patients. |
| first_indexed | 2024-03-12T03:00:59Z |
| format | Article |
| id | doaj.art-4dfd0e8694074859a25a0f7bd0486af8 |
| institution | Directory Open Access Journal |
| issn | 2313-7053 2713-055X |
| language | Russian |
| last_indexed | 2024-03-12T03:00:59Z |
| publishDate | 2023-07-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj.art-4dfd0e8694074859a25a0f7bd0486af82023-09-03T14:46:00ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2023-07-010010.31363/2313-7053-2023-674502Cognitive decline in patients with essential tremorM. M. Ermakova0Z. A. Zalyalova1Kazan State Medical University; Federal Center for Traumatology, Orthopedics and EndoprostheticsKazan State Medical University; Center for Scientific Medicine “Sikhat”Essential tremor (ET) is a heterogeneous disease with a high prevalence and disability. Traditionally, the disease was considered benign with the presence of tremor, the severity of which increases during the observation period. The severity of trembling varies widely from mild, not requiring therapy, to disabling. That is making difficulties to assess the prevalence of the disease. However, disability in patients with ET can occur not only due to the severity of tremor.The underestimated side of the disease, despite a long history of study, remains non-motor manifestations, including cognitive decline. Cognitive decline in essential tremor, compared with the general population, has a greater risk of transformation into dementia. In patients with ET, in comparison with other cognitive domains, executive functions are predominantly affected. Patients are also characterized by low awareness and concern about changes in intelligence. In the study of the brain using voxel morphometry, a heterogeneous group of changes that contradict each other was revealed. Most often, a change in the density of the cortex of different parts of the brain is detected in comparison with the control group. The most affected area of the brain is the precuneus. This may explain the executive dysfunction in patients and highlight the likely neurodegenerative nature of essential tremor. The absence of preventive therapy, the high incidence of changes in intelligence emphasizes the need for close monitoring of patients.https://www.bekhterevreview.com/jour/article/view/840essential tremorcognitive declinevoxel morphometry |
| spellingShingle | M. M. Ermakova Z. A. Zalyalova Cognitive decline in patients with essential tremor Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева essential tremor cognitive decline voxel morphometry |
| title | Cognitive decline in patients with essential tremor |
| title_full | Cognitive decline in patients with essential tremor |
| title_fullStr | Cognitive decline in patients with essential tremor |
| title_full_unstemmed | Cognitive decline in patients with essential tremor |
| title_short | Cognitive decline in patients with essential tremor |
| title_sort | cognitive decline in patients with essential tremor |
| topic | essential tremor cognitive decline voxel morphometry |
| url | https://www.bekhterevreview.com/jour/article/view/840 |
| work_keys_str_mv | AT mmermakova cognitivedeclineinpatientswithessentialtremor AT zazalyalova cognitivedeclineinpatientswithessentialtremor |