pIL6-TRAIL-engineered umbilical cord mesenchymal/stromal stem cells are highly cytotoxic for myeloma cells both in vitro and in vivo

pIL6-TRAIL-engineered umbilical cord mesenchymal/stromal stem cells are highly cytotoxic for myeloma cells both in vitro and in vivo

Abstract Background Mesenchymal/stromal stem cells (MSCs) are favorably regarded in anti-cancer cytotherapies for their spontaneous chemotaxis toward inflammatory and tumor environments associated with an intrinsic cytotoxicity against tumor cells. Placenta-derived or TRAIL-engineered adipose MSCs h...

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Bibliographic Details
Main Authors: Paola Cafforio, Luigi Viggiano, Francesco Mannavola, Eleonora Pellè, Concetta Caporusso, Eugenio Maiorano, Claudia Felici, Francesco Silvestris
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Stem Cell Research & Therapy
Subjects:
Multiple myeloma
Umbilical cord mesenchymal stromal/stem cells
TRAIL
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13287-017-0655-6

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