Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children
Seven-valent pneumococcal conjugate vaccine (PCV-7) is effective against vaccine serotype disease and carriage. Nevertheless, shifts in colonization and disease toward nonvaccine serotypes and other potential pathogens have been described. To understand the extent of these shifts, we analyzed nasoph...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2014-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/20/2/13-1220_article |
| _version_ | 1811293815600840704 |
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| author | Giske Biesbroek Xinhui Wang Bart J.F. Keijser Rene M.J. Eijkemans Krzysztof Trzciński Nynke Y. Rots Reinier H. Veenhoven Elisabeth A.M. Sanders Debby Bogaert |
| author_facet | Giske Biesbroek Xinhui Wang Bart J.F. Keijser Rene M.J. Eijkemans Krzysztof Trzciński Nynke Y. Rots Reinier H. Veenhoven Elisabeth A.M. Sanders Debby Bogaert |
| author_sort | Giske Biesbroek |
| collection | DOAJ |
| description | Seven-valent pneumococcal conjugate vaccine (PCV-7) is effective against vaccine serotype disease and carriage. Nevertheless, shifts in colonization and disease toward nonvaccine serotypes and other potential pathogens have been described. To understand the extent of these shifts, we analyzed nasopharyngeal microbial profiles of 97 PCV-7–vaccinated infants and 103 control infants participating in a randomized controlled trial in the Netherlands. PCV-7 immunization resulted in a temporary shift in microbial community composition and increased bacterial diversity. Immunization also resulted in decreased presence of the pneumococcal vaccine serotype and an increase in the relative abundance and presence of nonpneumococcal streptococci and anaerobic bacteria. Furthermore, the abundance of Haemophilus and Staphylococcus bacteria in vaccinees was increased over that in controls. This study illustrates the much broader effect of vaccination with PCV-7 on the microbial community than currently assumed, and highlights the need for careful monitoring when implementing vaccines directed against common colonizers.
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| first_indexed | 2024-04-13T05:07:23Z |
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| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-13T05:07:23Z |
| publishDate | 2014-02-01 |
| publisher | Centers for Disease Control and Prevention |
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| series | Emerging Infectious Diseases |
| spelling | doaj.art-4dfd9078d2974d58a27d6ecb5433e1c82022-12-22T03:01:08ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592014-02-0120220121010.3201/eid2002.131220Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy ChildrenGiske BiesbroekXinhui WangBart J.F. KeijserRene M.J. EijkemansKrzysztof TrzcińskiNynke Y. RotsReinier H. VeenhovenElisabeth A.M. SandersDebby BogaertSeven-valent pneumococcal conjugate vaccine (PCV-7) is effective against vaccine serotype disease and carriage. Nevertheless, shifts in colonization and disease toward nonvaccine serotypes and other potential pathogens have been described. To understand the extent of these shifts, we analyzed nasopharyngeal microbial profiles of 97 PCV-7–vaccinated infants and 103 control infants participating in a randomized controlled trial in the Netherlands. PCV-7 immunization resulted in a temporary shift in microbial community composition and increased bacterial diversity. Immunization also resulted in decreased presence of the pneumococcal vaccine serotype and an increase in the relative abundance and presence of nonpneumococcal streptococci and anaerobic bacteria. Furthermore, the abundance of Haemophilus and Staphylococcus bacteria in vaccinees was increased over that in controls. This study illustrates the much broader effect of vaccination with PCV-7 on the microbial community than currently assumed, and highlights the need for careful monitoring when implementing vaccines directed against common colonizers. Download MP3 Length: 1:39https://wwwnc.cdc.gov/eid/article/20/2/13-1220_articleseven-valent pneumococcal conjugate vaccinePCV-7pneumococcal conjugate vaccinepneumococcal conjugate vaccinationpneumococcibacteria |
| spellingShingle | Giske Biesbroek Xinhui Wang Bart J.F. Keijser Rene M.J. Eijkemans Krzysztof Trzciński Nynke Y. Rots Reinier H. Veenhoven Elisabeth A.M. Sanders Debby Bogaert Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children Emerging Infectious Diseases seven-valent pneumococcal conjugate vaccine PCV-7 pneumococcal conjugate vaccine pneumococcal conjugate vaccination pneumococci bacteria |
| title | Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children |
| title_full | Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children |
| title_fullStr | Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children |
| title_full_unstemmed | Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children |
| title_short | Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children |
| title_sort | seven valent pneumococcal conjugate vaccine and nasopharyngeal microbiota in healthy children |
| topic | seven-valent pneumococcal conjugate vaccine PCV-7 pneumococcal conjugate vaccine pneumococcal conjugate vaccination pneumococci bacteria |
| url | https://wwwnc.cdc.gov/eid/article/20/2/13-1220_article |
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