The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia
Abstract Background The cytogenetic aberrations were considered as markers for diagnosis and prognosis in acute myeloid leukemia (AML), while the expression and regulation under different cytogenetic groups remain to be fully elucidated. Methods In this paper, for favorable, poor, and cytogeneticall...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-09-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.1365 |
| _version_ | 1797301120165478400 |
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| author | Huili Wang Sheng‐Yan Lin Fei‐Fei Hu An‐Yuan Guo Hui Hu |
| author_facet | Huili Wang Sheng‐Yan Lin Fei‐Fei Hu An‐Yuan Guo Hui Hu |
| author_sort | Huili Wang |
| collection | DOAJ |
| description | Abstract Background The cytogenetic aberrations were considered as markers for diagnosis and prognosis in acute myeloid leukemia (AML), while the expression and regulation under different cytogenetic groups remain to be fully elucidated. Methods In this paper, for favorable, poor, and cytogenetically normal groups of AML patients, we performed comprehensive bioinformatics analyses including identifying differentially expressed genes (DEGs) and microRNAs (miRNAs) among them, functional enrichment and regulatory networks. Results We found that DEGs were enriched in membrane‐related processes. Eleven genes and two miRNAs were significantly differentially expressed among these three AML groups. In survival analysis, membrane‐related genes and several miRNAs were significant on prognostic outcome. Notably, six HOXA and three HOXB genes were significantly in low expression and high methylation in AML with favorable cytogenetics. Meanwhile, the miRNA‐HOX gene co‐regulatory networks revealed that HOXA5 was a hub node and regulated an AML oncogene SPARC. Conclusion Our work may provide novel insights to the molecular characteristics and classification between AML with different cytogenetics. |
| first_indexed | 2024-03-07T23:16:51Z |
| format | Article |
| id | doaj.art-4e01ae30748d4e518c973d50fd4ae0f7 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-03-07T23:16:51Z |
| publishDate | 2020-09-01 |
| publisher | Wiley |
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| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-4e01ae30748d4e518c973d50fd4ae0f72024-02-21T10:24:50ZengWileyMolecular Genetics & Genomic Medicine2324-92692020-09-0189n/an/a10.1002/mgg3.1365The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemiaHuili Wang0Sheng‐Yan Lin1Fei‐Fei Hu2An‐Yuan Guo3Hui Hu4Department of Environmental Engineering Wenhua College Wuhan ChinaHubei Bioinformatics & Molecular Imaging Key Laboratory College of Life Science and Technology Huazhong University of Science and Technology Wuhan ChinaHubei Bioinformatics & Molecular Imaging Key Laboratory College of Life Science and Technology Huazhong University of Science and Technology Wuhan ChinaHubei Bioinformatics & Molecular Imaging Key Laboratory College of Life Science and Technology Huazhong University of Science and Technology Wuhan ChinaHubei Bioinformatics & Molecular Imaging Key Laboratory College of Life Science and Technology Huazhong University of Science and Technology Wuhan ChinaAbstract Background The cytogenetic aberrations were considered as markers for diagnosis and prognosis in acute myeloid leukemia (AML), while the expression and regulation under different cytogenetic groups remain to be fully elucidated. Methods In this paper, for favorable, poor, and cytogenetically normal groups of AML patients, we performed comprehensive bioinformatics analyses including identifying differentially expressed genes (DEGs) and microRNAs (miRNAs) among them, functional enrichment and regulatory networks. Results We found that DEGs were enriched in membrane‐related processes. Eleven genes and two miRNAs were significantly differentially expressed among these three AML groups. In survival analysis, membrane‐related genes and several miRNAs were significant on prognostic outcome. Notably, six HOXA and three HOXB genes were significantly in low expression and high methylation in AML with favorable cytogenetics. Meanwhile, the miRNA‐HOX gene co‐regulatory networks revealed that HOXA5 was a hub node and regulated an AML oncogene SPARC. Conclusion Our work may provide novel insights to the molecular characteristics and classification between AML with different cytogenetics.https://doi.org/10.1002/mgg3.1365acute myeloid leukemiacytogenetics aberrationgene co‐regulatory networkHOX genemembrane protein |
| spellingShingle | Huili Wang Sheng‐Yan Lin Fei‐Fei Hu An‐Yuan Guo Hui Hu The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia Molecular Genetics & Genomic Medicine acute myeloid leukemia cytogenetics aberration gene co‐regulatory network HOX gene membrane protein |
| title | The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia |
| title_full | The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia |
| title_fullStr | The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia |
| title_full_unstemmed | The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia |
| title_short | The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia |
| title_sort | expression and regulation of hox genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia |
| topic | acute myeloid leukemia cytogenetics aberration gene co‐regulatory network HOX gene membrane protein |
| url | https://doi.org/10.1002/mgg3.1365 |
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