Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients
Background: The constantly increasing incidence of stroke in younger individuals substantiates an urgent need for research to elucidate underlying risk factors and etiologies. Heretofore, the vast majority of studies on stroke in the young have been carried out in European and North American regions...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.736818/full |
| _version_ | 1818990341068423168 |
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| author | Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Arturo Tamayo Arturo Tamayo Eyad Altarsha Annahita Sedghi Lars-Peder Pallesen Jessica Barlinn Volker Puetz Ben Min-Woo Illigens Kristian Barlinn Timo Siepmann |
| author_facet | Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Arturo Tamayo Arturo Tamayo Eyad Altarsha Annahita Sedghi Lars-Peder Pallesen Jessica Barlinn Volker Puetz Ben Min-Woo Illigens Kristian Barlinn Timo Siepmann |
| author_sort | Marwa Ahmed Eltemamy |
| collection | DOAJ |
| description | Background: The constantly increasing incidence of stroke in younger individuals substantiates an urgent need for research to elucidate underlying risk factors and etiologies. Heretofore, the vast majority of studies on stroke in the young have been carried out in European and North American regions. We aimed to characterize cerebrovascular risk profiles in a Saudi Arabic cohort of consecutive young stroke patients.Methods: We retrospectively analyzed data from consecutive ischemic stroke patients aged 15 to 49 years who underwent detailed cardiocerebrovascular evaluation at a tertiary stroke care center in Makkah, Saudi Arabia. Distributions of risk factors and stroke etiologies were assessed in the entire cohort and in two strata of very young (15–40 years) and young to middle-aged patients (41–49) to account for variability in suggested age cutoffs.Results: In the entire cohort [n = 63, ages 44 (34–47) median, interquartile range], dyslipidemia (71.4%) and small vessel occlusion (31.7%) displayed highest prevalence followed by diabetes (52.4%) and cardioembolism (19%). In very young patients, cardioembolism was the most prevalent etiology (27.3%). Risk profiles were similar between both age strata except for a higher prevalence of diabetes among the older cohort (31.8 vs. 63.4%, p = 0.01). Logistic regression identified diabetes as strongest predictor for association to the older strata (odds ratio = 4.2, 95% confidence interval = 1.2–14.1, p = 0.02).Conclusion: Cerebrovascular risk profiles and stroke etiologies in our cohort of young stroke patients differ from those of previous cohorts, suggesting the need for tailored prevention strategies that take into account local epidemiological data on cerebrovascular health. |
| first_indexed | 2024-12-20T19:52:50Z |
| format | Article |
| id | doaj.art-4e023659827e4186b2272652d098bd25 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T19:52:50Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4e023659827e4186b2272652d098bd252022-12-21T19:28:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-11-011210.3389/fneur.2021.736818736818Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke PatientsMarwa Ahmed Eltemamy0Marwa Ahmed Eltemamy1Marwa Ahmed Eltemamy2Arturo Tamayo3Arturo Tamayo4Eyad Altarsha5Annahita Sedghi6Lars-Peder Pallesen7Jessica Barlinn8Volker Puetz9Ben Min-Woo Illigens10Kristian Barlinn11Timo Siepmann12Department of Stroke Medicine, Fairfield General Hospital, Manchester, United KingdomDivision of Health Care Sciences, Center for Clinical Research and Management Education, Dresden International University, Dresden, GermanyDepartment of Neurology, King Abdullah Medical City, Mecca, Saudi ArabiaDivision of Health Care Sciences, Center for Clinical Research and Management Education, Dresden International University, Dresden, GermanyWinnipeg Regional Health Authority (WRHA), Department of Medicine, Section of Neurology, The Max Rady Faculty of Health Sciences, Brandon Regional Health Centre, University of Manitoba, Winnipeg, MB, CanadaDepartment of Neurology, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Neurology, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, GermanyDepartment of Neurology, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, GermanyBackground: The constantly increasing incidence of stroke in younger individuals substantiates an urgent need for research to elucidate underlying risk factors and etiologies. Heretofore, the vast majority of studies on stroke in the young have been carried out in European and North American regions. We aimed to characterize cerebrovascular risk profiles in a Saudi Arabic cohort of consecutive young stroke patients.Methods: We retrospectively analyzed data from consecutive ischemic stroke patients aged 15 to 49 years who underwent detailed cardiocerebrovascular evaluation at a tertiary stroke care center in Makkah, Saudi Arabia. Distributions of risk factors and stroke etiologies were assessed in the entire cohort and in two strata of very young (15–40 years) and young to middle-aged patients (41–49) to account for variability in suggested age cutoffs.Results: In the entire cohort [n = 63, ages 44 (34–47) median, interquartile range], dyslipidemia (71.4%) and small vessel occlusion (31.7%) displayed highest prevalence followed by diabetes (52.4%) and cardioembolism (19%). In very young patients, cardioembolism was the most prevalent etiology (27.3%). Risk profiles were similar between both age strata except for a higher prevalence of diabetes among the older cohort (31.8 vs. 63.4%, p = 0.01). Logistic regression identified diabetes as strongest predictor for association to the older strata (odds ratio = 4.2, 95% confidence interval = 1.2–14.1, p = 0.02).Conclusion: Cerebrovascular risk profiles and stroke etiologies in our cohort of young stroke patients differ from those of previous cohorts, suggesting the need for tailored prevention strategies that take into account local epidemiological data on cerebrovascular health.https://www.frontiersin.org/articles/10.3389/fneur.2021.736818/fullstrokeischemic strokestroke in youngSaudi Arabiarisk factorsjuvenile |
| spellingShingle | Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Marwa Ahmed Eltemamy Arturo Tamayo Arturo Tamayo Eyad Altarsha Annahita Sedghi Lars-Peder Pallesen Jessica Barlinn Volker Puetz Ben Min-Woo Illigens Kristian Barlinn Timo Siepmann Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients Frontiers in Neurology stroke ischemic stroke stroke in young Saudi Arabia risk factors juvenile |
| title | Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients |
| title_full | Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients |
| title_fullStr | Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients |
| title_full_unstemmed | Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients |
| title_short | Cerebrovascular Risk Profiles in a Saudi Arabian Cohort of Young Stroke Patients |
| title_sort | cerebrovascular risk profiles in a saudi arabian cohort of young stroke patients |
| topic | stroke ischemic stroke stroke in young Saudi Arabia risk factors juvenile |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.736818/full |
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