Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients
INTRODUCTION[|]Secondary hyperparathyroidism (SHPT) and anemia are the primary and most common complications in patients receiving hemodialysis (HD). Neutrophil gelatinase-associated lipocalin (NGAL) is a new marker to assess iron deficiency and manage iron therapy for HD patients. The aim of this s...
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KARE Publishing
2017-05-01
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| Series: | İstanbul Kuzey Klinikleri |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-59002 |
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| author | Irem Pembegul Yigit Ramazan Ulu Nevzat Gozel Hulya Taskapan Necip Ilhan Ayhan Dogukan |
| author_facet | Irem Pembegul Yigit Ramazan Ulu Nevzat Gozel Hulya Taskapan Necip Ilhan Ayhan Dogukan |
| author_sort | Irem Pembegul Yigit |
| collection | DOAJ |
| description | INTRODUCTION[|]Secondary hyperparathyroidism (SHPT) and anemia are the primary and most common complications in patients receiving hemodialysis (HD). Neutrophil gelatinase-associated lipocalin (NGAL) is a new marker to assess iron deficiency and manage iron therapy for HD patients. The aim of this study was to determine any association between serum NGAL level and anemia without iron deficiency in patients with SHPT on chronic HD.[¤]METHODS[|]Total of 61 SHPT patients on chronic HD were enrolled in the study and divided into 3 groups: mild SHPT group (n=17), moderate SHPT group (n=21), and severe SHPT group (n=23). Hemogram, biochemical assays, and level of ferritin, high sensitivity C-reactive protein (hs-CRP), and NGAL were evaluated in all groups.[¤]RESULTS[|]Serum NGAL level was significantly higher and hemoglobin (Hb) level was significantly lower in severe SHPT patients compared with both mild and moderate SHPT patients. Furthermore, in severe SHPT group, serum NGAL level was significantly positively correlated with serum parathyroid hormone (r=0.79; p=0.00) and hs-CRP (r=0.52; p=0.01) level and negatively correlated with serum Hb (r=-0.56; p=0.00) level.[¤]DISCUSSION AND CONCLUSION[|]SHPT was important factor affecting anemia in HD patients. Even when iron deficiency anemia is excluded in patients with SHPT, there was significant negative correlation between serum NGAL and Hb.[¤] |
| first_indexed | 2024-04-10T14:54:19Z |
| format | Article |
| id | doaj.art-4e023e0ba3394b3aa1418c8f654eb3fb |
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| issn | 2148-4902 |
| language | English |
| last_indexed | 2024-04-10T14:54:19Z |
| publishDate | 2017-05-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | İstanbul Kuzey Klinikleri |
| spelling | doaj.art-4e023e0ba3394b3aa1418c8f654eb3fb2023-02-15T16:07:26ZengKARE Publishingİstanbul Kuzey Klinikleri2148-49022017-05-0141364210.14744/nci.2017.59002NCI-59002Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patientsIrem Pembegul Yigit0Ramazan Ulu1Nevzat Gozel2Hulya Taskapan3Necip Ilhan4Ayhan Dogukan5Department of Nephrology, Malatya Government Hospital, Malatya, TurkeyDepartment of Nephrology, Firat University Faculty of Medicine, Elazig, TurkeyDepartment of Internal Medicine, Firat University Faculty of Medicine, Elazig, TurkeyDepartment of Nephrology, Inonu University Faculty of Medicine, Malatya, TurkeyDepartment of Biochemistry, Firat University Faculty of Medicine, Elazig, TurkeyDepartment of Nephrology, Firat University Faculty of Medicine, Elazig, TurkeyINTRODUCTION[|]Secondary hyperparathyroidism (SHPT) and anemia are the primary and most common complications in patients receiving hemodialysis (HD). Neutrophil gelatinase-associated lipocalin (NGAL) is a new marker to assess iron deficiency and manage iron therapy for HD patients. The aim of this study was to determine any association between serum NGAL level and anemia without iron deficiency in patients with SHPT on chronic HD.[¤]METHODS[|]Total of 61 SHPT patients on chronic HD were enrolled in the study and divided into 3 groups: mild SHPT group (n=17), moderate SHPT group (n=21), and severe SHPT group (n=23). Hemogram, biochemical assays, and level of ferritin, high sensitivity C-reactive protein (hs-CRP), and NGAL were evaluated in all groups.[¤]RESULTS[|]Serum NGAL level was significantly higher and hemoglobin (Hb) level was significantly lower in severe SHPT patients compared with both mild and moderate SHPT patients. Furthermore, in severe SHPT group, serum NGAL level was significantly positively correlated with serum parathyroid hormone (r=0.79; p=0.00) and hs-CRP (r=0.52; p=0.01) level and negatively correlated with serum Hb (r=-0.56; p=0.00) level.[¤]DISCUSSION AND CONCLUSION[|]SHPT was important factor affecting anemia in HD patients. Even when iron deficiency anemia is excluded in patients with SHPT, there was significant negative correlation between serum NGAL and Hb.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-59002anemiahemodialysishyperparathyroidismneutrophil gelatinase-associated lipocalin. |
| spellingShingle | Irem Pembegul Yigit Ramazan Ulu Nevzat Gozel Hulya Taskapan Necip Ilhan Ayhan Dogukan Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients İstanbul Kuzey Klinikleri anemia hemodialysis hyperparathyroidism neutrophil gelatinase-associated lipocalin. |
| title | Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients |
| title_full | Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients |
| title_fullStr | Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients |
| title_full_unstemmed | Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients |
| title_short | Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients |
| title_sort | neutrophil gelatinase associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients |
| topic | anemia hemodialysis hyperparathyroidism neutrophil gelatinase-associated lipocalin. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-59002 |
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