Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches

Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches

Drug resistance limits the effectiveness of oesophageal adenocarcinoma (OAC) chemotherapies, leading to a poor prognosis for this disease. Elucidation of the underlying resistance mechanisms is key to enabling the identification of more effective treatments. This study, therefore, aims to identify n...

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Bibliographic Details
Main Authors: Niamh H. McCabe, Leanne Stevenson, Enya Scanlon, Rosalie Douglas, Susanna Kennedy, Oliver Keminer, Björn Windshügel, Daniela Zisterer, Richard D. Kennedy, Jaine K. Blayney, Richard C. Turkington
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
oesophageal cancer
chemotherapy
drug resistance
siRNA screen
Online Access:https://www.mdpi.com/2072-6694/14/15/3726

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