CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2

CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2

Our previous work demonstrated that Piwil2 reactivated by the human papillomavirus oncoproteins E6 and E7 may reprogram somatic cells into tumor-initiating cells (TICs), which contribute to cervical neoplasia lesions. Maintaining the stemness of TICs is critical for the progression of cervical lesio...

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Bibliographic Details
Main Authors: Dingqing Feng, Keqin Yan, Haiyan Liang, Jing Liang, Wenhui Wang, Huan Yu, Ying Zhou, Weidong Zhao, Zhongjun Dong, Bin Ling
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Cervical cancer
Piwil2
Wnt signaling
Tumor initiating cell
CBP
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301688

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