A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?
<h4>Background</h4>We used fMRI to examine functional brain abnormalities of German-speaking dyslexics who suffer from slow effortful reading but not from a reading accuracy problem. Similar to acquired cases of letter-by-letter reading, the developmental cases exhibited an abnormal stro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-08-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20711448/?tool=EBI |
| _version_ | 1818838008987648000 |
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| author | Fabio Richlan Denise Sturm Matthias Schurz Martin Kronbichler Gunther Ladurner Heinz Wimmer |
| author_facet | Fabio Richlan Denise Sturm Matthias Schurz Martin Kronbichler Gunther Ladurner Heinz Wimmer |
| author_sort | Fabio Richlan |
| collection | DOAJ |
| description | <h4>Background</h4>We used fMRI to examine functional brain abnormalities of German-speaking dyslexics who suffer from slow effortful reading but not from a reading accuracy problem. Similar to acquired cases of letter-by-letter reading, the developmental cases exhibited an abnormal strong effect of length (i.e., number of letters) on response time for words and pseudowords.<h4>Results</h4>Corresponding to lesions of left occipito-temporal (OT) regions in acquired cases, we found a dysfunction of this region in our developmental cases who failed to exhibit responsiveness of left OT regions to the length of words and pseudowords. This abnormality in the left OT cortex was accompanied by absent responsiveness to increased sublexical reading demands in phonological inferior frontal gyrus (IFG) regions. Interestingly, there was no abnormality in the left superior temporal cortex which--corresponding to the onological deficit explanation--is considered to be the prime locus of the reading difficulties of developmental dyslexia cases.<h4>Conclusions</h4>The present functional imaging results suggest that developmental dyslexia similar to acquired letter-by-letter reading is due to a primary dysfunction of left OT regions. |
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| format | Article |
| id | doaj.art-4e06621c79e146de9102f5028d4c6b66 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T03:31:34Z |
| publishDate | 2010-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4e06621c79e146de9102f5028d4c6b662022-12-21T20:37:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-08-0158e1207310.1371/journal.pone.0012073A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading?Fabio RichlanDenise SturmMatthias SchurzMartin KronbichlerGunther LadurnerHeinz Wimmer<h4>Background</h4>We used fMRI to examine functional brain abnormalities of German-speaking dyslexics who suffer from slow effortful reading but not from a reading accuracy problem. Similar to acquired cases of letter-by-letter reading, the developmental cases exhibited an abnormal strong effect of length (i.e., number of letters) on response time for words and pseudowords.<h4>Results</h4>Corresponding to lesions of left occipito-temporal (OT) regions in acquired cases, we found a dysfunction of this region in our developmental cases who failed to exhibit responsiveness of left OT regions to the length of words and pseudowords. This abnormality in the left OT cortex was accompanied by absent responsiveness to increased sublexical reading demands in phonological inferior frontal gyrus (IFG) regions. Interestingly, there was no abnormality in the left superior temporal cortex which--corresponding to the onological deficit explanation--is considered to be the prime locus of the reading difficulties of developmental dyslexia cases.<h4>Conclusions</h4>The present functional imaging results suggest that developmental dyslexia similar to acquired letter-by-letter reading is due to a primary dysfunction of left OT regions.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20711448/?tool=EBI |
| spellingShingle | Fabio Richlan Denise Sturm Matthias Schurz Martin Kronbichler Gunther Ladurner Heinz Wimmer A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading? PLoS ONE |
| title | A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading? |
| title_full | A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading? |
| title_fullStr | A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading? |
| title_full_unstemmed | A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading? |
| title_short | A common left occipito-temporal dysfunction in developmental dyslexia and acquired letter-by-letter reading? |
| title_sort | common left occipito temporal dysfunction in developmental dyslexia and acquired letter by letter reading |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20711448/?tool=EBI |
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