Diagnosis, Follow-Up and Treatment Results in Thyroid Ophthalmopathy
Objectives: To discuss our follow-up and treatment results in thyroid-associated ophthalmopathy (TAO). Materials and Methods: The records of 168 TAO cases who were followed at our clinic between October 1998 and October 2013 were reviewed retrospectively. The severity and activity of the disease w...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2015-08-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.oftalmoloji.org/article_9133/Diagnosis-Follow-up-And-Treatment-Results-In-Thyroid-Ophthalmopathy |
| _version_ | 1797918617025642496 |
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| author | Esra Savku Kaan Gündüz |
| author_facet | Esra Savku Kaan Gündüz |
| author_sort | Esra Savku |
| collection | DOAJ |
| description | Objectives: To discuss our follow-up and treatment results in thyroid-associated ophthalmopathy (TAO).
Materials and Methods: The records of 168 TAO cases who were followed at our clinic between October 1998 and October 2013
were reviewed retrospectively. The severity and activity of the disease were evaluated according to the criteria of the European Group on
Graves’ Ophthalmopathy (EUGOGO) and Clinical Activity Score (CAS).
Results: Sixty-three men and 105 women participated in the study. The mean age of the patients was 42.3±12.4 years. Smoking habit
was noted in 54.2% of the cases. Graves’ disease was the most common (80.4%) thyroid pathology accompanying TAO. TAO was mild
in 64.4%, moderate-to-severe in 33.6% and severe in 2% of the eyes. Male gender was found as an independent risk factor for severity
of the disease (p=0.040). TAO was in the active phase in 32.6% of the eyes. Older age and high thyroid receptor antibody titer were
correlated with disease activity (P=0.031 and P<0.001, respectively). Thirty-four patients (20%) were treated for ocular findings. The
most common treatment was systemic steroid therapy (12%); others included orbital decompression (5%), orbital radiotherapy (2%),
and topical application of guanethidine (1%).
Conclusion: Non-infiltrative phase and mild ocular findings were generally seen in TAO. Therefore, treatment is not recommended for
many cases. Systemic steroid therapy is the most commonly used treatment modality in the active phase. However, orbital decompression
surgery is necessary in a small number of cases with sight-threatening ocular findings. (Turk J Ophthalmol 2015; 45: 156-163) |
| first_indexed | 2024-04-10T13:33:22Z |
| format | Article |
| id | doaj.art-4e06a692f66947928e5488adb851dc8b |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T13:33:22Z |
| publishDate | 2015-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-4e06a692f66947928e5488adb851dc8b2023-02-15T16:11:30ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612015-08-0145415616310.4274/tjo.93609Diagnosis, Follow-Up and Treatment Results in Thyroid OphthalmopathyEsra Savku0Kaan Gündüz1Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Ophthalmology, Ankara, TurkeyObjectives: To discuss our follow-up and treatment results in thyroid-associated ophthalmopathy (TAO). Materials and Methods: The records of 168 TAO cases who were followed at our clinic between October 1998 and October 2013 were reviewed retrospectively. The severity and activity of the disease were evaluated according to the criteria of the European Group on Graves’ Ophthalmopathy (EUGOGO) and Clinical Activity Score (CAS). Results: Sixty-three men and 105 women participated in the study. The mean age of the patients was 42.3±12.4 years. Smoking habit was noted in 54.2% of the cases. Graves’ disease was the most common (80.4%) thyroid pathology accompanying TAO. TAO was mild in 64.4%, moderate-to-severe in 33.6% and severe in 2% of the eyes. Male gender was found as an independent risk factor for severity of the disease (p=0.040). TAO was in the active phase in 32.6% of the eyes. Older age and high thyroid receptor antibody titer were correlated with disease activity (P=0.031 and P<0.001, respectively). Thirty-four patients (20%) were treated for ocular findings. The most common treatment was systemic steroid therapy (12%); others included orbital decompression (5%), orbital radiotherapy (2%), and topical application of guanethidine (1%). Conclusion: Non-infiltrative phase and mild ocular findings were generally seen in TAO. Therefore, treatment is not recommended for many cases. Systemic steroid therapy is the most commonly used treatment modality in the active phase. However, orbital decompression surgery is necessary in a small number of cases with sight-threatening ocular findings. (Turk J Ophthalmol 2015; 45: 156-163)http://www.oftalmoloji.org/article_9133/Diagnosis-Follow-up-And-Treatment-Results-In-Thyroid-OphthalmopathyClinical activity scoreorbital decompressionorbital radiotherapysmokingthyroid-associated ophthalmopathy |
| spellingShingle | Esra Savku Kaan Gündüz Diagnosis, Follow-Up and Treatment Results in Thyroid Ophthalmopathy Türk Oftalmoloji Dergisi Clinical activity score orbital decompression orbital radiotherapy smoking thyroid-associated ophthalmopathy |
| title | Diagnosis, Follow-Up and Treatment Results in Thyroid Ophthalmopathy |
| title_full | Diagnosis, Follow-Up and Treatment Results in Thyroid Ophthalmopathy |
| title_fullStr | Diagnosis, Follow-Up and Treatment Results in Thyroid Ophthalmopathy |
| title_full_unstemmed | Diagnosis, Follow-Up and Treatment Results in Thyroid Ophthalmopathy |
| title_short | Diagnosis, Follow-Up and Treatment Results in Thyroid Ophthalmopathy |
| title_sort | diagnosis follow up and treatment results in thyroid ophthalmopathy |
| topic | Clinical activity score orbital decompression orbital radiotherapy smoking thyroid-associated ophthalmopathy |
| url | http://www.oftalmoloji.org/article_9133/Diagnosis-Follow-up-And-Treatment-Results-In-Thyroid-Ophthalmopathy |
| work_keys_str_mv | AT esrasavku diagnosisfollowupandtreatmentresultsinthyroidophthalmopathy AT kaangunduz diagnosisfollowupandtreatmentresultsinthyroidophthalmopathy |