Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphoma
<b>Objective:</b> This series of six intestinal T cell lymphomas (ITCL) attempts to document enteropathy-associated T cell lymphoma (EATCL) in India. <b>Materials and Methods:</b> A total of six ITCL were selected from 170 gastrointestinal lymphomas in last 10 years. <b>...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=3;spage=455;epage=459;aulast=Shet |
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| author | Shet Tanuja Karpate Arti Bal Munita Gupta Sudeep Gujral Sumeet Nair Reena |
| author_facet | Shet Tanuja Karpate Arti Bal Munita Gupta Sudeep Gujral Sumeet Nair Reena |
| author_sort | Shet Tanuja |
| collection | DOAJ |
| description | <b>Objective:</b> This series of six intestinal T cell lymphomas (ITCL) attempts to document enteropathy-associated T cell lymphoma (EATCL) in India. <b>Materials and Methods:</b> A total of six ITCL were selected from 170 gastrointestinal lymphomas in last 10 years. <b>Results:</b> The cases studied included EATCL (4), ITCL with a CD4 positive phenotype (1) and ITCL NK/T cell type (1). Of the four EATCL, two occurred in the ileum, one in right colon and one in duodenum. In three EATCL cases, there was history of celiac disease or lactose intolerance and enteropathic changes were noted in the adjacent mucosa. These tumors had CD3+/CD8+/CD56 (+/-)/CD4-/ Granzyme B+ immunophenotype. One EATCL was monomorphic small cell type (type II EATCL) with a CD3+/CD8-CD56+/CD4-/ Granzyme B+ phenotype. EBER- ISH (Epstein Barr virus coded RNA′s- in situ hybridization) revealed positive tumor cells in ITCL NK/T cell type and in bystander cells in three EATCL. <b>Conclusion:</b> ITCL are rare in Indian patients but do occur and comprise a mixture of the enteropathic and non-enteropathic subtypes. |
| first_indexed | 2024-04-12T03:00:36Z |
| format | Article |
| id | doaj.art-4e077f1b6fe5480ab831816284016a1c |
| institution | Directory Open Access Journal |
| issn | 0377-4929 0974-5130 |
| language | English |
| last_indexed | 2024-04-12T03:00:36Z |
| publishDate | 2010-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-4e077f1b6fe5480ab831816284016a1c2022-12-22T03:50:40ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302010-07-01533455459Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphomaShet TanujaKarpate ArtiBal MunitaGupta SudeepGujral SumeetNair Reena<b>Objective:</b> This series of six intestinal T cell lymphomas (ITCL) attempts to document enteropathy-associated T cell lymphoma (EATCL) in India. <b>Materials and Methods:</b> A total of six ITCL were selected from 170 gastrointestinal lymphomas in last 10 years. <b>Results:</b> The cases studied included EATCL (4), ITCL with a CD4 positive phenotype (1) and ITCL NK/T cell type (1). Of the four EATCL, two occurred in the ileum, one in right colon and one in duodenum. In three EATCL cases, there was history of celiac disease or lactose intolerance and enteropathic changes were noted in the adjacent mucosa. These tumors had CD3+/CD8+/CD56 (+/-)/CD4-/ Granzyme B+ immunophenotype. One EATCL was monomorphic small cell type (type II EATCL) with a CD3+/CD8-CD56+/CD4-/ Granzyme B+ phenotype. EBER- ISH (Epstein Barr virus coded RNA′s- in situ hybridization) revealed positive tumor cells in ITCL NK/T cell type and in bystander cells in three EATCL. <b>Conclusion:</b> ITCL are rare in Indian patients but do occur and comprise a mixture of the enteropathic and non-enteropathic subtypes.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=3;spage=455;epage=459;aulast=ShetCeliac diseaseenteropathyintestinal lymphomaT cell lymphoma |
| spellingShingle | Shet Tanuja Karpate Arti Bal Munita Gupta Sudeep Gujral Sumeet Nair Reena Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphoma Indian Journal of Pathology and Microbiology Celiac disease enteropathy intestinal lymphoma T cell lymphoma |
| title | Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphoma |
| title_full | Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphoma |
| title_fullStr | Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphoma |
| title_full_unstemmed | Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphoma |
| title_short | Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphoma |
| title_sort | primary intestinal t cell lymphomas in indian patients in search of enteropathic t cell lymphoma |
| topic | Celiac disease enteropathy intestinal lymphoma T cell lymphoma |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=3;spage=455;epage=459;aulast=Shet |
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