Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease
There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an e...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/9/1211 |
| _version_ | 1797556776922513408 |
|---|---|
| author | Diana Maria Chitimus Mihaela Roxana Popescu Suzana Elena Voiculescu Anca Maria Panaitescu Bogdan Pavel Leon Zagrean Ana-Maria Zagrean |
| author_facet | Diana Maria Chitimus Mihaela Roxana Popescu Suzana Elena Voiculescu Anca Maria Panaitescu Bogdan Pavel Leon Zagrean Ana-Maria Zagrean |
| author_sort | Diana Maria Chitimus |
| collection | DOAJ |
| description | There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. The anti-inflammatory and antioxidant effects of melatonin are intertwined and are exerted throughout pregnancy and later during development and aging. Melatonin supplementation during pregnancy can reduce ischemia-induced oxidative damage in the fetal brain, increase offspring survival in inflammatory states, and reduce blood pressure in the adult offspring. In adulthood, disturbances in melatonin production negatively impact the progression of cardiovascular risk factors and promote cardiovascular and neurodegenerative diseases. The most studied cardiovascular effects of melatonin are linked to hypertension and myocardial ischemia/reperfusion injury, while the most promising ones are linked to regaining control of metabolic syndrome components. In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COVID 19). The present review summarizes and comments on important data regarding the roles exerted by melatonin in homeostasis and oxidative stress and inflammation related pathologies. |
| first_indexed | 2024-03-10T17:07:46Z |
| format | Article |
| id | doaj.art-4e07d6a9a0634d0091794e8dc0275dca |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T17:07:46Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-4e07d6a9a0634d0091794e8dc0275dca2023-11-20T10:45:56ZengMDPI AGBiomolecules2218-273X2020-08-01109121110.3390/biom10091211Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and DiseaseDiana Maria Chitimus0Mihaela Roxana Popescu1Suzana Elena Voiculescu2Anca Maria Panaitescu3Bogdan Pavel4Leon Zagrean5Ana-Maria Zagrean6Division of Physiology and Neuroscience, Department of Functional Sciences, “Carol Davila” University of Medicine and Pharmacy, 010164 Bucharest, RomaniaDepartment of Cardiology, “Carol Davila” University of Medicine and Pharmacy, Elias University Hospital, 010164 Bucharest, RomaniaDivision of Physiology and Neuroscience, Department of Functional Sciences, “Carol Davila” University of Medicine and Pharmacy, 010164 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Filantropia Clinical Hospital, 010164 Bucharest, RomaniaDivision of Physiology and Neuroscience, Department of Functional Sciences, “Carol Davila” University of Medicine and Pharmacy, 010164 Bucharest, RomaniaDivision of Physiology and Neuroscience, Department of Functional Sciences, “Carol Davila” University of Medicine and Pharmacy, 010164 Bucharest, RomaniaDivision of Physiology and Neuroscience, Department of Functional Sciences, “Carol Davila” University of Medicine and Pharmacy, 010164 Bucharest, RomaniaThere is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. The anti-inflammatory and antioxidant effects of melatonin are intertwined and are exerted throughout pregnancy and later during development and aging. Melatonin supplementation during pregnancy can reduce ischemia-induced oxidative damage in the fetal brain, increase offspring survival in inflammatory states, and reduce blood pressure in the adult offspring. In adulthood, disturbances in melatonin production negatively impact the progression of cardiovascular risk factors and promote cardiovascular and neurodegenerative diseases. The most studied cardiovascular effects of melatonin are linked to hypertension and myocardial ischemia/reperfusion injury, while the most promising ones are linked to regaining control of metabolic syndrome components. In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COVID 19). The present review summarizes and comments on important data regarding the roles exerted by melatonin in homeostasis and oxidative stress and inflammation related pathologies.https://www.mdpi.com/2218-273X/10/9/1211melatoninantioxidanthomeostasisallostasismaternal-fetal signalingCOVID 19 |
| spellingShingle | Diana Maria Chitimus Mihaela Roxana Popescu Suzana Elena Voiculescu Anca Maria Panaitescu Bogdan Pavel Leon Zagrean Ana-Maria Zagrean Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease Biomolecules melatonin antioxidant homeostasis allostasis maternal-fetal signaling COVID 19 |
| title | Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease |
| title_full | Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease |
| title_fullStr | Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease |
| title_full_unstemmed | Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease |
| title_short | Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease |
| title_sort | melatonin s impact on antioxidative and anti inflammatory reprogramming in homeostasis and disease |
| topic | melatonin antioxidant homeostasis allostasis maternal-fetal signaling COVID 19 |
| url | https://www.mdpi.com/2218-273X/10/9/1211 |
| work_keys_str_mv | AT dianamariachitimus melatoninsimpactonantioxidativeandantiinflammatoryreprogramminginhomeostasisanddisease AT mihaelaroxanapopescu melatoninsimpactonantioxidativeandantiinflammatoryreprogramminginhomeostasisanddisease AT suzanaelenavoiculescu melatoninsimpactonantioxidativeandantiinflammatoryreprogramminginhomeostasisanddisease AT ancamariapanaitescu melatoninsimpactonantioxidativeandantiinflammatoryreprogramminginhomeostasisanddisease AT bogdanpavel melatoninsimpactonantioxidativeandantiinflammatoryreprogramminginhomeostasisanddisease AT leonzagrean melatoninsimpactonantioxidativeandantiinflammatoryreprogramminginhomeostasisanddisease AT anamariazagrean melatoninsimpactonantioxidativeandantiinflammatoryreprogramminginhomeostasisanddisease |