THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer
Prostate cancer is one of the most common malignancies, and there are a wide range of treatment options after diagnosis. Most prostate cancers behave in an indolent manner. However, a given sub-group has been shown to exhibit aggressive behavior; therefore, it is desirable to find novel prognostic a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/2/221 |
| _version_ | 1797443826518851584 |
|---|---|
| author | Fidelis Andrea Flockerzi Johannes Hohneck Matthias Saar Rainer Maria Bohle Phillip Rolf Stahl |
| author_facet | Fidelis Andrea Flockerzi Johannes Hohneck Matthias Saar Rainer Maria Bohle Phillip Rolf Stahl |
| author_sort | Fidelis Andrea Flockerzi |
| collection | DOAJ |
| description | Prostate cancer is one of the most common malignancies, and there are a wide range of treatment options after diagnosis. Most prostate cancers behave in an indolent manner. However, a given sub-group has been shown to exhibit aggressive behavior; therefore, it is desirable to find novel prognostic and predictive (molecular) markers. THSD7A expression is significantly associated with unfavorable prognostic parameters in prostate cancer. FAK is overexpressed in several tumor types and is believed to play a role in tumor progression and metastasis. Furthermore, there is evidence that THSD7A might affect FAK-dependent signaling pathways. To examine whether THSD7A expression has an impact on the expression level of FAK in its unphosphorylated form, a total of 461 prostate cancers were analyzed by immunohistochemistry using tissue microarrays. THSD7A positivity and low FAK expression were associated with adverse pathological features. THSD7A positivity was significantly associated with high FAK expression. To our knowledge we are the first to show that THSD7A positivity is associated with high FAK expression in prostate cancer. This might be proof of the actual involvement of THSD7A in FAK-dependent signaling pathways. This is of special importance because THSD7A might also serve as a putative therapeutic target in cancer therapy. |
| first_indexed | 2024-03-09T13:03:39Z |
| format | Article |
| id | doaj.art-4e0898bf36864a76a63f11fcca4b6ece |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T13:03:39Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4e0898bf36864a76a63f11fcca4b6ece2023-11-30T21:51:41ZengMDPI AGDiagnostics2075-44182023-01-0113222110.3390/diagnostics13020221THSD7A Positivity Is Associated with High Expression of FAK in Prostate CancerFidelis Andrea Flockerzi0Johannes Hohneck1Matthias Saar2Rainer Maria Bohle3Phillip Rolf Stahl4Department of Pathology, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Pathology, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Urology, University Hospital, 52074 Aachen, GermanyDepartment of Pathology, Saarland University Medical Center, 66421 Homburg, GermanyDepartment of Pathology, Saarland University Medical Center, 66421 Homburg, GermanyProstate cancer is one of the most common malignancies, and there are a wide range of treatment options after diagnosis. Most prostate cancers behave in an indolent manner. However, a given sub-group has been shown to exhibit aggressive behavior; therefore, it is desirable to find novel prognostic and predictive (molecular) markers. THSD7A expression is significantly associated with unfavorable prognostic parameters in prostate cancer. FAK is overexpressed in several tumor types and is believed to play a role in tumor progression and metastasis. Furthermore, there is evidence that THSD7A might affect FAK-dependent signaling pathways. To examine whether THSD7A expression has an impact on the expression level of FAK in its unphosphorylated form, a total of 461 prostate cancers were analyzed by immunohistochemistry using tissue microarrays. THSD7A positivity and low FAK expression were associated with adverse pathological features. THSD7A positivity was significantly associated with high FAK expression. To our knowledge we are the first to show that THSD7A positivity is associated with high FAK expression in prostate cancer. This might be proof of the actual involvement of THSD7A in FAK-dependent signaling pathways. This is of special importance because THSD7A might also serve as a putative therapeutic target in cancer therapy.https://www.mdpi.com/2075-4418/13/2/221THSD7AFAKprostate cancer |
| spellingShingle | Fidelis Andrea Flockerzi Johannes Hohneck Matthias Saar Rainer Maria Bohle Phillip Rolf Stahl THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer Diagnostics THSD7A FAK prostate cancer |
| title | THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer |
| title_full | THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer |
| title_fullStr | THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer |
| title_full_unstemmed | THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer |
| title_short | THSD7A Positivity Is Associated with High Expression of FAK in Prostate Cancer |
| title_sort | thsd7a positivity is associated with high expression of fak in prostate cancer |
| topic | THSD7A FAK prostate cancer |
| url | https://www.mdpi.com/2075-4418/13/2/221 |
| work_keys_str_mv | AT fidelisandreaflockerzi thsd7apositivityisassociatedwithhighexpressionoffakinprostatecancer AT johanneshohneck thsd7apositivityisassociatedwithhighexpressionoffakinprostatecancer AT matthiassaar thsd7apositivityisassociatedwithhighexpressionoffakinprostatecancer AT rainermariabohle thsd7apositivityisassociatedwithhighexpressionoffakinprostatecancer AT philliprolfstahl thsd7apositivityisassociatedwithhighexpressionoffakinprostatecancer |