Spinal mechanisms of neuropathic pain: Is there a P2X4-BDNF controversy?
More than a decade ago the novel concept that glial cells are major players in the modulation of pain mechanisms in the spinal cord has started a prolific series of work addressing the modalities of neuron-glia communication. Mike Salter with Kazuhide Inoue laboratories introduced ATP as pivotal med...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Neurobiology of Pain |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452073X17300016 |
| _version_ | 1818559120102391808 |
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| author | Marzia Malcangio |
| author_facet | Marzia Malcangio |
| author_sort | Marzia Malcangio |
| collection | DOAJ |
| description | More than a decade ago the novel concept that glial cells are major players in the modulation of pain mechanisms in the spinal cord has started a prolific series of work addressing the modalities of neuron-glia communication. Mike Salter with Kazuhide Inoue laboratories introduced ATP as pivotal mediator for such communication via activation of P2X4 receptors expressed by microglia in the dorsal horn ipsilateral to a peripheral nerve injury. Activation of P2X4 receptors result in release of the neurotrophin BDNF, which, through the activation of neuronal TrkB receptors, alters neuronal excitability and this effect is associated with behavioural ipsilateral allodynia. This viewpoint article compares the evidence supporting a biological relevance of the P2X4 and BDNF system in neuropathic pain with recent data which question such importance. Having read this article, readers will be able to formulate their own opinion on such controversy. |
| first_indexed | 2024-12-14T00:21:14Z |
| format | Article |
| id | doaj.art-4e09a29407c24bb89237392b093681da |
| institution | Directory Open Access Journal |
| issn | 2452-073X |
| language | English |
| last_indexed | 2024-12-14T00:21:14Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Pain |
| spelling | doaj.art-4e09a29407c24bb89237392b093681da2022-12-21T23:25:13ZengElsevierNeurobiology of Pain2452-073X2017-01-01115Spinal mechanisms of neuropathic pain: Is there a P2X4-BDNF controversy?Marzia Malcangio0Wolfson Centre for Age Related Diseases, IoPPN, King’s College London, United KingdomMore than a decade ago the novel concept that glial cells are major players in the modulation of pain mechanisms in the spinal cord has started a prolific series of work addressing the modalities of neuron-glia communication. Mike Salter with Kazuhide Inoue laboratories introduced ATP as pivotal mediator for such communication via activation of P2X4 receptors expressed by microglia in the dorsal horn ipsilateral to a peripheral nerve injury. Activation of P2X4 receptors result in release of the neurotrophin BDNF, which, through the activation of neuronal TrkB receptors, alters neuronal excitability and this effect is associated with behavioural ipsilateral allodynia. This viewpoint article compares the evidence supporting a biological relevance of the P2X4 and BDNF system in neuropathic pain with recent data which question such importance. Having read this article, readers will be able to formulate their own opinion on such controversy.http://www.sciencedirect.com/science/article/pii/S2452073X17300016 |
| spellingShingle | Marzia Malcangio Spinal mechanisms of neuropathic pain: Is there a P2X4-BDNF controversy? Neurobiology of Pain |
| title | Spinal mechanisms of neuropathic pain: Is there a P2X4-BDNF controversy? |
| title_full | Spinal mechanisms of neuropathic pain: Is there a P2X4-BDNF controversy? |
| title_fullStr | Spinal mechanisms of neuropathic pain: Is there a P2X4-BDNF controversy? |
| title_full_unstemmed | Spinal mechanisms of neuropathic pain: Is there a P2X4-BDNF controversy? |
| title_short | Spinal mechanisms of neuropathic pain: Is there a P2X4-BDNF controversy? |
| title_sort | spinal mechanisms of neuropathic pain is there a p2x4 bdnf controversy |
| url | http://www.sciencedirect.com/science/article/pii/S2452073X17300016 |
| work_keys_str_mv | AT marziamalcangio spinalmechanismsofneuropathicpainisthereap2x4bdnfcontroversy |