Interactions between Radiation and One-Carbon Metabolism
Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/3/1919 |
| _version_ | 1797487083407802368 |
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| author | Navyateja Korimerla Daniel R. Wahl |
| author_facet | Navyateja Korimerla Daniel R. Wahl |
| author_sort | Navyateja Korimerla |
| collection | DOAJ |
| description | Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism. This review discusses the interactions between radiation therapy, one-carbon metabolism and its component metabolic pathways. |
| first_indexed | 2024-03-09T23:42:47Z |
| format | Article |
| id | doaj.art-4e0ae8f29819400a9512f9cd151e6bdd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:42:47Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4e0ae8f29819400a9512f9cd151e6bdd2023-11-23T16:48:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01233191910.3390/ijms23031919Interactions between Radiation and One-Carbon MetabolismNavyateja Korimerla0Daniel R. Wahl1Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USADepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USAMetabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism. This review discusses the interactions between radiation therapy, one-carbon metabolism and its component metabolic pathways.https://www.mdpi.com/1422-0067/23/3/1919one-carbon metabolismradiation therapycancer therapyfolate cyclemethionine cycle |
| spellingShingle | Navyateja Korimerla Daniel R. Wahl Interactions between Radiation and One-Carbon Metabolism International Journal of Molecular Sciences one-carbon metabolism radiation therapy cancer therapy folate cycle methionine cycle |
| title | Interactions between Radiation and One-Carbon Metabolism |
| title_full | Interactions between Radiation and One-Carbon Metabolism |
| title_fullStr | Interactions between Radiation and One-Carbon Metabolism |
| title_full_unstemmed | Interactions between Radiation and One-Carbon Metabolism |
| title_short | Interactions between Radiation and One-Carbon Metabolism |
| title_sort | interactions between radiation and one carbon metabolism |
| topic | one-carbon metabolism radiation therapy cancer therapy folate cycle methionine cycle |
| url | https://www.mdpi.com/1422-0067/23/3/1919 |
| work_keys_str_mv | AT navyatejakorimerla interactionsbetweenradiationandonecarbonmetabolism AT danielrwahl interactionsbetweenradiationandonecarbonmetabolism |