Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®”
The intensity of free-radical processes upon long-term omeprazole-induced hypoacidity in the rat pancreas was investigated. Significant violation of oxidative-antioxidative balance in pancreatic tissue upon gastric hypochlorhydria was established: overproduction of superoxide anion, quantitative cha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2013-04-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Dvorshchenko_2_13.pdf |
| _version_ | 1797422295806902272 |
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| author | K. O. Dvorshchenko S. Ye. Vakal A. S. Dranitsina S. A. Senin L. I. Ostapchenko |
| author_facet | K. O. Dvorshchenko S. Ye. Vakal A. S. Dranitsina S. A. Senin L. I. Ostapchenko |
| author_sort | K. O. Dvorshchenko |
| collection | DOAJ |
| description | The intensity of free-radical processes upon long-term omeprazole-induced hypoacidity in the rat pancreas was investigated. Significant violation of oxidative-antioxidative balance in pancreatic tissue upon gastric hypochlorhydria was established: overproduction of superoxide anion, quantitative changes of lipid functional groups, increased level of lipid peroxidation products, augmentation of xanthine oxidase, superoxide dismutase and glutathione transferase activity, as well as depletion of catalase, glutathione peroxidase activity and reduced glutathione content. The inflected expression of Cckbr gene in the rat pancreas upon these conditions was also observed, thus suggesting an increased risk of pathological changes development in the gland. Abovementioned parameters were only partially restored to control values in the case of simultaneous administration of multiprobiotic “Symbiter®” with omeprazole, thus indicating the ability of this preparation to efficiently counteract the development of oxidative damages in pancreatic tissues upon long-term hypoacidic conditions. |
| first_indexed | 2024-03-09T07:30:08Z |
| format | Article |
| id | doaj.art-4e0cc5074cdf4f4abe6219446195a5ff |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T07:30:08Z |
| publishDate | 2013-04-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-4e0cc5074cdf4f4abe6219446195a5ff2023-12-03T06:27:15ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032013-04-01852687710.15407/ubj85.02.068Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®”K. O. Dvorshchenko0S. Ye. Vakal1A. S. Dranitsina2S. A. Senin3L. I. Ostapchenko4Taras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineTaras Shevchenko National University of Kyiv, UkraineThe intensity of free-radical processes upon long-term omeprazole-induced hypoacidity in the rat pancreas was investigated. Significant violation of oxidative-antioxidative balance in pancreatic tissue upon gastric hypochlorhydria was established: overproduction of superoxide anion, quantitative changes of lipid functional groups, increased level of lipid peroxidation products, augmentation of xanthine oxidase, superoxide dismutase and glutathione transferase activity, as well as depletion of catalase, glutathione peroxidase activity and reduced glutathione content. The inflected expression of Cckbr gene in the rat pancreas upon these conditions was also observed, thus suggesting an increased risk of pathological changes development in the gland. Abovementioned parameters were only partially restored to control values in the case of simultaneous administration of multiprobiotic “Symbiter®” with omeprazole, thus indicating the ability of this preparation to efficiently counteract the development of oxidative damages in pancreatic tissues upon long-term hypoacidic conditions.http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Dvorshchenko_2_13.pdfantioxidant systemgene expressionhypochlorhydrialipid peroxidationpancreasprobioticssuperoxide anion |
| spellingShingle | K. O. Dvorshchenko S. Ye. Vakal A. S. Dranitsina S. A. Senin L. I. Ostapchenko Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®” The Ukrainian Biochemical Journal antioxidant system gene expression hypochlorhydria lipid peroxidation pancreas probiotics superoxide anion |
| title | Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®” |
| title_full | Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®” |
| title_fullStr | Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®” |
| title_full_unstemmed | Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®” |
| title_short | Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®” |
| title_sort | stress responsive systems in rat pancreas upon long term gastric hypochlorhydria and administration of multiprobiotic symbiter r |
| topic | antioxidant system gene expression hypochlorhydria lipid peroxidation pancreas probiotics superoxide anion |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/10/Dvorshchenko_2_13.pdf |
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